| Name | SIK1 |
| ID | P57059 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 27-278 PROSITE-ProRule
UBA 303-343 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK1 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 16817901 | SIGNOR-147707 |
| SIK1 | CRTC2 | Ser348 | PSLQSSLsNPNLQAS | phosphorylation down-regulates activity | 16306228 | SIGNOR-249168 |
| SIK1 | CRTC2 | Ser70 | RSSHYGGsLPNVNQI | phosphorylation down-regulates activity | 16306228 | SIGNOR-249169 |
| SIK1 | CRTC3 | Ser162 | SALNRTNsDSALHTS | phosphorylation down-regulates | 16817901 | SIGNOR-147703 |
| SIK1 | CRTC1 | Ser167 | MTPTQPEsFSSGSQD | phosphorylation down-regulates | 16817901 | SIGNOR-147669 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK1 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16817901 | SIGNOR-147707 |
| SIK1 | phosphorylation up-regulates → | CRTC2 PSer348 | phosphorylation down-regulates ⊣ | CRTC2 | 16306228 | SIGNOR-249168 |
| SIK1 | phosphorylation up-regulates → | CRTC2 PSer70 | phosphorylation down-regulates ⊣ | CRTC2 | 16306228 | SIGNOR-249169 |
| SIK1 | phosphorylation up-regulates → | CRTC3 PSer162 | phosphorylation down-regulates ⊣ | CRTC3 | 16817901 | SIGNOR-147703 |
| SIK1 | phosphorylation up-regulates → | CRTC1 PSer167 | phosphorylation down-regulates ⊣ | CRTC1 | 16817901 | SIGNOR-147669 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SIK1 | phosphorylation down-regulates | CRTC2 | SIGNOR-147707 |
| SIK1 | phosphorylation → down-regulates activity | CRTC2 | SIGNOR-249168 |
| SIK1 | phosphorylation → down-regulates activity | CRTC2 | SIGNOR-249169 |
| SIK1 | phosphorylation down-regulates | CRTC3 | SIGNOR-147703 |
| SIK1 | phosphorylation down-regulates | CRTC1 | SIGNOR-147669 |