| Name | SIK1 |
| ID | P57059 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 27-278 PROSITE-ProRule
UBA 303-343 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | SIK1 | Thr182 | KSGEPLStWCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122784 |
| AKT | SIK1 | Ser435 | VFRPRPVsPSSLLDT | phosphorylation down-regulates activity | 36806887 | SIGNOR-277835 |
| GSK3B | SIK1 | – | phosphorylation up-regulates activity | 18348280 | SIGNOR-279742 | |
| STK11 | SIK1 | Thr182 | KSGEPLStWCGSPPY | phosphorylation up-regulates activity | 18946175 | SIGNOR-262844 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | phosphorylation up-regulates → | SIK1 PThr182 | phosphorylation up-regulates → | SIK1 | 14976552 | SIGNOR-122784 |
| AKT | phosphorylation up-regulates → | SIK1 PSer435 | phosphorylation down-regulates ⊣ | SIK1 | 36806887 | SIGNOR-277835 |
| STK11 | phosphorylation up-regulates → | SIK1 PThr182 | phosphorylation up-regulates → | SIK1 | 18946175 | SIGNOR-262844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK11 | phosphorylation → up-regulates | SIK1 | SIGNOR-122784 |
| AKT | phosphorylation → down-regulates activity | SIK1 | SIGNOR-277835 |
| GSK3B | phosphorylation → up-regulates activity | SIK1 | SIGNOR-279742 |
| STK11 | phosphorylation → up-regulates activity | SIK1 | SIGNOR-262844 |