| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | SIK1 | Ser435 | VFRPRPVsPSSLLDT | phosphorylation down-regulates activity | 36806887 | SIGNOR-277835 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | SIK1 PSer435 | phosphorylation down-regulates ⊣ | SIK1 | 36806887 | SIGNOR-277835 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | SIK1 | SIGNOR-277835 |
