| Name | PTEN |
| ID | P60484 |
| Role | phosphatase |
| Enzymatic Domains |
Phosphatase tensin-type 14-185 PROSITE-ProRule
C2 tensin-type 190-350 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | DVL2 | Ser143 | FHPNVSSsHENLEPE | dephosphorylation down-regulates activity | 26399523 | SIGNOR-277035 |
| PTEN | SP1 | – | dephosphorylation down-regulates activity | 21603612 | SIGNOR-277119 | |
| PTEN | AR | Ser83 | QQQQQETsPRQQQQQ | dephosphorylation up-regulates activity | 24480624 | SIGNOR-277077 |
| PTEN | MAPT | – | dephosphorylation up-regulates activity | 27221467 | SIGNOR-277079 | |
| PTEN | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22482061 | SIGNOR-277009 |
| PTEN | CREB1 | Ser119 | EILSRRPsYRKILND | dephosphorylation down-regulates activity | 21385900 | SIGNOR-248543 |
| PTEN | NCL | Thr84 | PAKKAAVtPGKKAAA | dephosphorylation up-regulates activity | 28332494 | SIGNOR-277166 |
| PTEN | RPS6KB1 | – | dephosphorylation down-regulates activity | 19436944 | SIGNOR-277080 | |
| PTEN | CFL1 | – | dephosphorylation up-regulates activity | 22317922 | SIGNOR-276980 | |
| PTEN | IRS1 | Ser307 | TRRSRTEsITATSPA | dephosphorylation down-regulates activity | 25645159 | SIGNOR-277078 |
| PTEN | STAT5A | – | dephosphorylation down-regulates | 20596030 | SIGNOR-166481 | |
| PTEN | RAB7A | Ser72 | AGQERFQsLGVAFYR | dephosphorylation up-regulates activity | 26869029 | SIGNOR-276960 |
| PTEN | RAB7A | Tyr183 | QETEVELyNEFPEPI | dephosphorylation up-regulates activity | 26869029 | SIGNOR-276959 |
| PTEN | KIF11 | Thr926 | LDIPTGTtPQRKSYL | dephosphorylation up-regulates activity | 27492783 | SIGNOR-277000 |
| PTEN | PTEN | Ser380 | EPDHYRYsDTTDSDP | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248544 |
| PTEN | PTEN | Thr382 | DHYRYSDtTDSDPEN | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248546 |
| PTEN | PTEN | Thr383 | HYRYSDTtDSDPENE | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248545 |
| PTEN | PFKP | Ser386 | AVRLRGRsFAGNLNT | dephosphorylation down-regulates activity | 29038421 | SIGNOR-277118 |
| PTEN | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 10400703 | SIGNOR-248547 |
| PTEN | GRIN2B | – | dephosphorylation down-regulates activity | 33348808 | SIGNOR-277165 | |
| PTEN | NR5A1 | – | dephosphorylation down-regulates activity | 27838257 | SIGNOR-277117 | |
| PTEN | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | dephosphorylation down-regulates activity | 29142193 | SIGNOR-276975 |
| PTEN | IRF3 | Ser97 | LRLAEDRsKDPHDPH | dephosphorylation up-regulates activity | 32394474 | SIGNOR-277025 |
| PTEN | ABI1 | Ser216 | VPNDYMTsPARLGSQ | dephosphorylation down-regulates quantity by destabilization | 32673396 | SIGNOR-276949 |
| PTEN | ABI1 | Tyr213 | PPTVPNDyMTSPARL | dephosphorylation down-regulates quantity by destabilization | 32673396 | SIGNOR-276948 |
| PTEN | NKX3-1 | Thr179 | FQNRRYKtKRKQLSS | dephosphorylation up-regulates quantity by stabilization | 31213464 | SIGNOR-277026 |
| PTEN | BCR-ABL | – | dephosphorylation down-regulates activity | 31374292 | SIGNOR-260080 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | DVL2 PSer143 | dephosphorylation up-regulates → | DVL2 | 26399523 | SIGNOR-277035 |
| PTEN | dephosphorylation down-regulates ⊣ | AR PSer83 | dephosphorylation down-regulates ⊣ | AR | 24480624 | SIGNOR-277077 |
| PTEN | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22482061 | SIGNOR-277009 |
| PTEN | dephosphorylation down-regulates ⊣ | CREB1 PSer119 | dephosphorylation up-regulates → | CREB1 | 21385900 | SIGNOR-248543 |
| PTEN | dephosphorylation down-regulates ⊣ | NCL PThr84 | dephosphorylation down-regulates ⊣ | NCL | 28332494 | SIGNOR-277166 |
| PTEN | dephosphorylation down-regulates ⊣ | IRS1 PSer307 | dephosphorylation up-regulates → | IRS1 | 25645159 | SIGNOR-277078 |
| PTEN | dephosphorylation down-regulates ⊣ | RAB7A PSer72 | dephosphorylation down-regulates ⊣ | RAB7A | 26869029 | SIGNOR-276960 |
| PTEN | dephosphorylation down-regulates ⊣ | RAB7A PTyr183 | dephosphorylation down-regulates ⊣ | RAB7A | 26869029 | SIGNOR-276959 |
| PTEN | dephosphorylation down-regulates ⊣ | KIF11 PThr926 | dephosphorylation down-regulates ⊣ | KIF11 | 27492783 | SIGNOR-277000 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PSer380 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248544 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PThr382 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248546 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PThr383 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248545 |
| PTEN | dephosphorylation down-regulates ⊣ | PFKP PSer386 | dephosphorylation up-regulates → | PFKP | 29038421 | SIGNOR-277118 |
| PTEN | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 10400703 | SIGNOR-248547 |
| PTEN | dephosphorylation down-regulates ⊣ | PTK6 PTyr342 | dephosphorylation up-regulates → | PTK6 | 29142193 | SIGNOR-276975 |
| PTEN | dephosphorylation down-regulates ⊣ | IRF3 PSer97 | dephosphorylation down-regulates ⊣ | IRF3 | 32394474 | SIGNOR-277025 |
| PTEN | dephosphorylation down-regulates ⊣ | ABI1 PSer216 | dephosphorylation up-regulates → | ABI1 | 32673396 | SIGNOR-276949 |
| PTEN | dephosphorylation down-regulates ⊣ | ABI1 PTyr213 | dephosphorylation up-regulates → | ABI1 | 32673396 | SIGNOR-276948 |
| PTEN | dephosphorylation down-regulates ⊣ | NKX3-1 PThr179 | dephosphorylation down-regulates ⊣ | NKX3-1 | 31213464 | SIGNOR-277026 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → down-regulates activity | DVL2 | SIGNOR-277035 |
| PTEN | dephosphorylation → down-regulates activity | SP1 | SIGNOR-277119 |
| PTEN | dephosphorylation → up-regulates activity | AR | SIGNOR-277077 |
| PTEN | dephosphorylation → up-regulates activity | MAPT | SIGNOR-277079 |
| PTEN | dephosphorylation → down-regulates activity | SRC | SIGNOR-277009 |
| PTEN | dephosphorylation → down-regulates activity | CREB1 | SIGNOR-248543 |
| PTEN | dephosphorylation → up-regulates activity | NCL | SIGNOR-277166 |
| PTEN | dephosphorylation → down-regulates activity | RPS6KB1 | SIGNOR-277080 |
| PTEN | dephosphorylation → up-regulates activity | CFL1 | SIGNOR-276980 |
| PTEN | dephosphorylation → down-regulates activity | IRS1 | SIGNOR-277078 |
| PTEN | dephosphorylation down-regulates | STAT5A | SIGNOR-166481 |
| PTEN | dephosphorylation → up-regulates activity | RAB7A | SIGNOR-276960 |
| PTEN | dephosphorylation → up-regulates activity | RAB7A | SIGNOR-276959 |
| PTEN | dephosphorylation → up-regulates activity | KIF11 | SIGNOR-277000 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248544 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248546 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248545 |
| PTEN | dephosphorylation → down-regulates activity | PFKP | SIGNOR-277118 |
| PTEN | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248547 |
| PTEN | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-277165 |
| PTEN | dephosphorylation → down-regulates activity | NR5A1 | SIGNOR-277117 |
| PTEN | dephosphorylation → down-regulates activity | PTK6 | SIGNOR-276975 |
| PTEN | dephosphorylation → up-regulates activity | IRF3 | SIGNOR-277025 |
| PTEN | dephosphorylation down-regulates quantity by destabilization | ABI1 | SIGNOR-276949 |
| PTEN | dephosphorylation down-regulates quantity by destabilization | ABI1 | SIGNOR-276948 |
| PTEN | dephosphorylation → up-regulates quantity by stabilization | NKX3-1 | SIGNOR-277026 |
| PTEN | dephosphorylation → down-regulates activity | BCR-ABL | SIGNOR-260080 |