| Name | PTEN |
| ID | P60484 |
| Role | substrate |
| Enzymatic Domains |
Phosphatase tensin-type 14-185 PROSITE-ProRule
C2 tensin-type 190-350 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 12297295 | SIGNOR-251026 |
| FGFR2 | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation unknown | 22891331 | SIGNOR-191793 |
| GSK3B | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 16107342 | SIGNOR-236641 |
| PTP4A3 | PTEN | – | dephosphorylation down-regulates quantity by destabilization | 29266303 | SIGNOR-277010 | |
| MAST2 | PTEN | – | phosphorylation up-regulates | 15951562 | SIGNOR-138051 | |
| PLK3 | PTEN | Ser370 | TSVTPDVsDNEPDHY | phosphorylation down-regulates activity | 20940307 | SIGNOR-168469 |
| PLK3 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 20940307 | SIGNOR-168473 |
| PINK1 | PTEN | Ser179 | RRYVYYYsYLLKNHL | phosphorylation down-regulates activity | 37940999 | SIGNOR-277915 |
| SRC | PTEN | – | phosphorylation down-regulates | 12869565 | SIGNOR-103721 | |
| CSNK2A1 | PTEN | Ser370 | TSVTPDVsDNEPDHY | phosphorylation down-regulates activity | 21779440 | SIGNOR-89818 |
| CSNK2A1 | PTEN | Thr383 | HYRYSDTtDSDPENE | phosphorylation down-regulates activity | 21779440 | SIGNOR-89830 |
| CSNK2A1 | PTEN | Thr382 | DHYRYSDtTDSDPEN | phosphorylation down-regulates activity | 21779440 | SIGNOR-89826 |
| STK11 | PTEN | Thr382 | DHYRYSDtTDSDPEN | phosphorylation down-regulates activity | 21779440 | SIGNOR-161122 |
| CSNK2A2 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation down-regulates activity | 12297295 | SIGNOR-251027 |
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates activity | 11948419 | SIGNOR-275983 |
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates | 11948419 | SIGNOR-116499 |
| SRC | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates activity | 11948419 | SIGNOR-275981 |
| CSNK2A1 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 12297295 | SIGNOR-250940 |
| FGFR3 | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation unknown | 22891331 | SIGNOR-191797 |
| ROCK1 | PTEN | Thr232 | YSSNSGPtRREDKFM | phosphorylation up-regulates | 15793569 | SIGNOR-134855 |
| INPP4B | PTEN | – | dephosphorylation down-regulates activity | 26411369 | SIGNOR-277018 | |
| STK11 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation unknown | 15987703 | SIGNOR-247446 |
| PBK | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 24012691 | SIGNOR-271472 |
| MAST3 | PTEN | – | phosphorylation unknown | 15951562 | SIGNOR-138080 | |
| STK11 | PTEN | Thr383 | HYRYSDTtDSDPENE | phosphorylation down-regulates activity | 18321849 | SIGNOR-161126 |
| MAST1 | PTEN | – | phosphorylation down-regulates | 15951562 | SIGNOR-138003 | |
| CSNK2A1 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation down-regulates activity | 21779440 | SIGNOR-89822 |
| PLK1 | PTEN | – | phosphorylation down-regulates activity | 27330107 | SIGNOR-280070 | |
| FRK | PTEN | Tyr336 | NKDKANRyFSPNFKV | phosphorylation up-regulates quantity by stabilization | 19345329 | SIGNOR-275458 |
| INSR | PTEN | Tyr174 | TIPSQRRyVYYYSYL | phosphorylation down-regulates activity | 23995781 | SIGNOR-276471 |
| FRK | PTEN | Tyr336 | NKDKANRyFSPNFKV | phosphorylation up-regulates activity | 19345329 | SIGNOR-278244 |
| INSR | PTEN | Tyr27 | GFDLDLTyIYPNIIA | phosphorylation down-regulates activity | 23995781 | SIGNOR-276470 |
| PTEN | PTEN | Thr382 | DHYRYSDtTDSDPEN | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248546 |
| LIMK2 | PTEN | – | phosphorylation down-regulates activity | 32931887 | SIGNOR-278363 | |
| SRC | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation up-regulates activity | 11948419 | SIGNOR-275982 |
| CSNK2A1 | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 21779440 | SIGNOR-152348 |
| LCK | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation up-regulates activity | 11948419 | SIGNOR-275984 |
| CSNK2A2 | PTEN | Ser370 | TSVTPDVsDNEPDHY | phosphorylation down-regulates activity | 12297295 | SIGNOR-251025 |
| STK11 | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 21779440 | SIGNOR-161118 |
| PTEN | PTEN | Thr383 | HYRYSDTtDSDPENE | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248545 |
| PTEN | PTEN | Ser380 | EPDHYRYsDTTDSDP | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248544 |
| ROCK1 | PTEN | Ser229 | VKIYSSNsGPTRRED | phosphorylation up-regulates | 15793569 | SIGNOR-134851 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-251026 |
| FGFR2 | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation down-regulates ⊣ | PTEN | 22891331 | SIGNOR-191793 |
| GSK3B | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 16107342 | SIGNOR-236641 |
| PLK3 | phosphorylation up-regulates → | PTEN PSer370 | phosphorylation down-regulates ⊣ | PTEN | 20940307 | SIGNOR-168469 |
| PLK3 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 20940307 | SIGNOR-168473 |
| PINK1 | phosphorylation up-regulates → | PTEN PSer179 | phosphorylation down-regulates ⊣ | PTEN | 37940999 | SIGNOR-277915 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PSer370 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-89818 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PThr383 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-89830 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PThr382 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-89826 |
| STK11 | phosphorylation up-regulates → | PTEN PThr382 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-161122 |
| CSNK2A2 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-251027 |
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275983 |
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-116499 |
| SRC | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275981 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-250940 |
| FGFR3 | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation down-regulates ⊣ | PTEN | 22891331 | SIGNOR-191797 |
| ROCK1 | phosphorylation up-regulates → | PTEN PThr232 | phosphorylation up-regulates → | PTEN | 15793569 | SIGNOR-134855 |
| STK11 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 15987703 | SIGNOR-247446 |
| PBK | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 24012691 | SIGNOR-271472 |
| STK11 | phosphorylation up-regulates → | PTEN PThr383 | phosphorylation down-regulates ⊣ | PTEN | 18321849 | SIGNOR-161126 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-89822 |
| FRK | phosphorylation up-regulates → | PTEN PTyr336 | phosphorylation up-regulates → | PTEN | 19345329 | SIGNOR-275458 |
| INSR | phosphorylation up-regulates → | PTEN PTyr174 | phosphorylation down-regulates ⊣ | PTEN | 23995781 | SIGNOR-276471 |
| FRK | phosphorylation up-regulates → | PTEN PTyr336 | phosphorylation up-regulates → | PTEN | 19345329 | SIGNOR-278244 |
| INSR | phosphorylation up-regulates → | PTEN PTyr27 | phosphorylation down-regulates ⊣ | PTEN | 23995781 | SIGNOR-276470 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PThr382 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248546 |
| SRC | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275982 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-152348 |
| LCK | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275984 |
| CSNK2A2 | phosphorylation up-regulates → | PTEN PSer370 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-251025 |
| STK11 | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-161118 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PThr383 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248545 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PSer380 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248544 |
| ROCK1 | phosphorylation up-regulates → | PTEN PSer229 | phosphorylation up-regulates → | PTEN | 15793569 | SIGNOR-134851 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-251026 |
| FGFR2 | phosphorylation → unknown | PTEN | SIGNOR-191793 |
| GSK3B | phosphorylation → down-regulates activity | PTEN | SIGNOR-236641 |
| PTP4A3 | dephosphorylation down-regulates quantity by destabilization | PTEN | SIGNOR-277010 |
| MAST2 | phosphorylation → up-regulates | PTEN | SIGNOR-138051 |
| PLK3 | phosphorylation → down-regulates activity | PTEN | SIGNOR-168469 |
| PLK3 | phosphorylation → down-regulates activity | PTEN | SIGNOR-168473 |
| PINK1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-277915 |
| SRC | phosphorylation down-regulates | PTEN | SIGNOR-103721 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-89818 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-89830 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-89826 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161122 |
| CSNK2A2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-251027 |
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275983 |
| LCK | phosphorylation → up-regulates | PTEN | SIGNOR-116499 |
| SRC | phosphorylation → up-regulates activity | PTEN | SIGNOR-275981 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-250940 |
| FGFR3 | phosphorylation → unknown | PTEN | SIGNOR-191797 |
| ROCK1 | phosphorylation → up-regulates | PTEN | SIGNOR-134855 |
| INPP4B | dephosphorylation → down-regulates activity | PTEN | SIGNOR-277018 |
| STK11 | phosphorylation → unknown | PTEN | SIGNOR-247446 |
| PBK | phosphorylation → down-regulates activity | PTEN | SIGNOR-271472 |
| MAST3 | phosphorylation → unknown | PTEN | SIGNOR-138080 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161126 |
| MAST1 | phosphorylation down-regulates | PTEN | SIGNOR-138003 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-89822 |
| PLK1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-280070 |
| FRK | phosphorylation → up-regulates quantity by stabilization | PTEN | SIGNOR-275458 |
| INSR | phosphorylation → down-regulates activity | PTEN | SIGNOR-276471 |
| FRK | phosphorylation → up-regulates activity | PTEN | SIGNOR-278244 |
| INSR | phosphorylation → down-regulates activity | PTEN | SIGNOR-276470 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248546 |
| LIMK2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-278363 |
| SRC | phosphorylation → up-regulates activity | PTEN | SIGNOR-275982 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-152348 |
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275984 |
| CSNK2A2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-251025 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161118 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248545 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248544 |
| ROCK1 | phosphorylation → up-regulates | PTEN | SIGNOR-134851 |