| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PBK | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 24012691 | SIGNOR-271472 |
| CSNK2A1 | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 21779440 | SIGNOR-152348 |
| STK11 | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 21779440 | SIGNOR-161118 |
| PTEN | PTEN | Ser380 | EPDHYRYsDTTDSDP | dephosphorylation up-regulates activity | 22413754 | SIGNOR-248544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PBK | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 24012691 | SIGNOR-271472 |
| CSNK2A1 | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-152348 |
| STK11 | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-161118 |
| PTEN | dephosphorylation down-regulates ⊣ | PTEN PSer380 | dephosphorylation down-regulates ⊣ | PTEN | 22413754 | SIGNOR-248544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PBK | phosphorylation → down-regulates activity | PTEN | SIGNOR-271472 |
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-152348 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161118 |
| PTEN | dephosphorylation → up-regulates activity | PTEN | SIGNOR-248544 |