| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 12297295 | SIGNOR-250940 |
| CSNK2A2 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 12297295 | SIGNOR-251026 |
| GSK3B | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 16107342 | SIGNOR-236641 |
| PLK3 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 20940307 | SIGNOR-168473 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-250940 |
| CSNK2A2 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-251026 |
| GSK3B | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 16107342 | SIGNOR-236641 |
| PLK3 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 20940307 | SIGNOR-168473 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-250940 |
| CSNK2A2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-251026 |
| GSK3B | phosphorylation → down-regulates activity | PTEN | SIGNOR-236641 |
| PLK3 | phosphorylation → down-regulates activity | PTEN | SIGNOR-168473 |