| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation down-regulates activity | 21779440 | SIGNOR-89822 |
| CSNK2A2 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation down-regulates activity | 12297295 | SIGNOR-251027 |
| STK11 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation unknown | 15987703 | SIGNOR-247446 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-89822 |
| CSNK2A2 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 12297295 | SIGNOR-251027 |
| STK11 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 15987703 | SIGNOR-247446 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-89822 |
| CSNK2A2 | phosphorylation → down-regulates activity | PTEN | SIGNOR-251027 |
| STK11 | phosphorylation → unknown | PTEN | SIGNOR-247446 |