| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR2 | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation unknown | 22891331 | SIGNOR-191793 |
| FGFR3 | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation unknown | 22891331 | SIGNOR-191797 |
| SRC | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation up-regulates activity | 11948419 | SIGNOR-275982 |
| LCK | PTEN | Tyr240 | RREDKFMyFEFPQPL | phosphorylation up-regulates activity | 11948419 | SIGNOR-275984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR2 | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation down-regulates ⊣ | PTEN | 22891331 | SIGNOR-191793 |
| FGFR3 | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation down-regulates ⊣ | PTEN | 22891331 | SIGNOR-191797 |
| SRC | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275982 |
| LCK | phosphorylation up-regulates → | PTEN PTyr240 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275984 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FGFR2 | phosphorylation → unknown | PTEN | SIGNOR-191793 |
| FGFR3 | phosphorylation → unknown | PTEN | SIGNOR-191797 |
| SRC | phosphorylation → up-regulates activity | PTEN | SIGNOR-275982 |
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275984 |
