| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | PTEN | Tyr174 | TIPSQRRyVYYYSYL | phosphorylation down-regulates activity | 23995781 | SIGNOR-276471 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | PTEN PTyr174 | phosphorylation down-regulates ⊣ | PTEN | 23995781 | SIGNOR-276471 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → down-regulates activity | PTEN | SIGNOR-276471 |