| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates activity | 11948419 | SIGNOR-275983 |
| LCK | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates | 11948419 | SIGNOR-116499 |
| SRC | PTEN | Tyr315 | RADNDKEyLVLTLTK | phosphorylation up-regulates activity | 11948419 | SIGNOR-275981 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275983 |
| LCK | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-116499 |
| SRC | phosphorylation up-regulates → | PTEN PTyr315 | phosphorylation up-regulates → | PTEN | 11948419 | SIGNOR-275981 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | PTEN | SIGNOR-275983 |
| LCK | phosphorylation → up-regulates | PTEN | SIGNOR-116499 |
| SRC | phosphorylation → up-regulates activity | PTEN | SIGNOR-275981 |