| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | HDAC3 | Ser424 | DHDNDKEsDVEI | dephosphorylation down-regulates activity | 15805470 | SIGNOR-248548 |
| PPP4C | BANF1 | Ser4 | sQKHRDFV | dephosphorylation up-regulates | 16495336 | SIGNOR-144779 |
| PPP4C | BANF1 | Ser4 | sQKHRDFV | dephosphorylation up-regulates | 24265311 | SIGNOR-203281 |
| PPP4C | CDK1 | – | dephosphorylation down-regulates activity | 18347064 | SIGNOR-277162 | |
| PPP4C | PLK1 | Ser137 | LELCRRRsLLELHKR | dephosphorylation down-regulates activity | 35546066 | SIGNOR-277076 |
| PPP4C | RELA | Thr435 | PTQAGEGtLSEALLQ | dephosphorylation up-regulates activity | 15073167 | SIGNOR-248549 |
| PPP4C | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264451 |
| PPP4C | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264450 |
| PPP4C | ACACA | Ser80 | LHIRSSMsGLHLVKQ | dephosphorylation up-regulates activity | 25050742 | SIGNOR-267724 |
| PPP4C | TRIM28 | – | dephosphorylation down-regulates activity | 22732494 | SIGNOR-277163 | |
| PPP4C | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | dephosphorylation down-regulates activity | 18347064 | SIGNOR-248550 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | HDAC3 PSer424 | dephosphorylation up-regulates → | HDAC3 | 15805470 | SIGNOR-248548 |
| PPP4C | dephosphorylation down-regulates ⊣ | BANF1 PSer4 | dephosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144779 |
| PPP4C | dephosphorylation down-regulates ⊣ | BANF1 PSer4 | dephosphorylation down-regulates ⊣ | BANF1 | 24265311 | SIGNOR-203281 |
| PPP4C | dephosphorylation down-regulates ⊣ | PLK1 PSer137 | dephosphorylation up-regulates → | PLK1 | 35546066 | SIGNOR-277076 |
| PPP4C | dephosphorylation down-regulates ⊣ | RELA PThr435 | dephosphorylation down-regulates ⊣ | RELA | 15073167 | SIGNOR-248549 |
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PSer1618 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264451 |
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PThr1609 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264450 |
| PPP4C | dephosphorylation down-regulates ⊣ | ACACA PSer80 | dephosphorylation down-regulates ⊣ | ACACA | 25050742 | SIGNOR-267724 |
| PPP4C | dephosphorylation down-regulates ⊣ | NDEL1 PThr219 | dephosphorylation up-regulates → | NDEL1 | 18347064 | SIGNOR-248550 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → down-regulates activity | HDAC3 | SIGNOR-248548 |
| PPP4C | dephosphorylation → up-regulates | BANF1 | SIGNOR-144779 |
| PPP4C | dephosphorylation → up-regulates | BANF1 | SIGNOR-203281 |
| PPP4C | dephosphorylation → down-regulates activity | CDK1 | SIGNOR-277162 |
| PPP4C | dephosphorylation → down-regulates activity | PLK1 | SIGNOR-277076 |
| PPP4C | dephosphorylation → up-regulates activity | RELA | SIGNOR-248549 |
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264451 |
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264450 |
| PPP4C | dephosphorylation → up-regulates activity | ACACA | SIGNOR-267724 |
| PPP4C | dephosphorylation → down-regulates activity | TRIM28 | SIGNOR-277163 |
| PPP4C | dephosphorylation → down-regulates activity | NDEL1 | SIGNOR-248550 |
