| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| KHK | PRPS1 | Thr225 | LVDDMADtCGTICHA | phosphorylation up-regulates activity | 29074724 | SIGNOR-265735 |
| CDK1 | PRPS1 | Ser103 | RQDKKDKsRAPISAK | phosphorylation up-regulates activity | 31253668 | SIGNOR-265728 |
| AMPK | PRPS1 | Ser180 | GGAKRVTsIADRLNV | phosphorylation down-regulates activity | 29074724 | SIGNOR-265730 |
| LATS1 | PRPS1 | Ser285 | EDKMKHCsKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276505 |
| TBK1 | PRPS1 | Thr228 | DMADTCGtICHAADK | phosphorylation up-regulates activity | 34343500 | SIGNOR-277316 |
| LATS2 | PRPS1 | Ser285 | EDKMKHCsKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276504 |
| PRKAA1 | PRPS1 | Ser180 | GGAKRVTsIADRLNV | phosphorylation down-regulates activity | 29074724 | SIGNOR-265729 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| KHK | phosphorylation up-regulates → | PRPS1 PThr225 | phosphorylation up-regulates → | PRPS1 | 29074724 | SIGNOR-265735 |
| CDK1 | phosphorylation up-regulates → | PRPS1 PSer103 | phosphorylation up-regulates → | PRPS1 | 31253668 | SIGNOR-265728 |
| AMPK | phosphorylation up-regulates → | PRPS1 PSer180 | phosphorylation down-regulates ⊣ | PRPS1 | 29074724 | SIGNOR-265730 |
| LATS1 | phosphorylation up-regulates → | PRPS1 PSer285 | phosphorylation down-regulates ⊣ | PRPS1 | 34465890 | SIGNOR-276505 |
| TBK1 | phosphorylation up-regulates → | PRPS1 PThr228 | phosphorylation up-regulates → | PRPS1 | 34343500 | SIGNOR-277316 |
| LATS2 | phosphorylation up-regulates → | PRPS1 PSer285 | phosphorylation down-regulates ⊣ | PRPS1 | 34465890 | SIGNOR-276504 |
| PRKAA1 | phosphorylation up-regulates → | PRPS1 PSer180 | phosphorylation down-regulates ⊣ | PRPS1 | 29074724 | SIGNOR-265729 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| KHK | phosphorylation → up-regulates activity | PRPS1 | SIGNOR-265735 |
| CDK1 | phosphorylation → up-regulates activity | PRPS1 | SIGNOR-265728 |
| AMPK | phosphorylation → down-regulates activity | PRPS1 | SIGNOR-265730 |
| LATS1 | phosphorylation down-regulates quantity by destabilization | PRPS1 | SIGNOR-276505 |
| TBK1 | phosphorylation → up-regulates activity | PRPS1 | SIGNOR-277316 |
| LATS2 | phosphorylation down-regulates quantity by destabilization | PRPS1 | SIGNOR-276504 |
| PRKAA1 | phosphorylation → down-regulates activity | PRPS1 | SIGNOR-265729 |
