| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK5 | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation down-regulates quantity | 24632620 | SIGNOR-279740 |
| PRKCD | CXCR4 | Ser338 | KGKRGGHsSVSTESE | phosphorylation down-regulates activity | 10521508 | SIGNOR-260900 |
| PRKD1 | CXCR4 | Ser324 | LTSVSRGsSLKILSK | phosphorylation down-regulates quantity | 27127886 | SIGNOR-279264 |
| PIM1 | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation up-regulates quantity | 26075720 | SIGNOR-278450 |
| PRKD1 | CXCR4 | Ser325 | TSVSRGSsLKILSKG | phosphorylation down-regulates quantity | 27127886 | SIGNOR-279263 |
| PRKCD | CXCR4 | Ser325 | LTSVSRGsSLKILSK | phosphorylation down-regulates activity | 10521508 | SIGNOR-260899 |
| PRKCD | CXCR4 | Ser324 | LTSVSRGsSLKILSK | phosphorylation down-regulates activity | 10521508 | SIGNOR-260898 |
| PIM3 | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation up-regulates quantity | 26075720 | SIGNOR-279092 |
| PRKCD | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation down-regulates activity | 10521508 | SIGNOR-260901 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK5 | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation down-regulates ⊣ | CXCR4 | 24632620 | SIGNOR-279740 |
| PRKCD | phosphorylation up-regulates → | CXCR4 PSer338 | phosphorylation down-regulates ⊣ | CXCR4 | 10521508 | SIGNOR-260900 |
| PRKD1 | phosphorylation up-regulates → | CXCR4 PSer324 | phosphorylation down-regulates ⊣ | CXCR4 | 27127886 | SIGNOR-279264 |
| PIM1 | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation up-regulates → | CXCR4 | 26075720 | SIGNOR-278450 |
| PRKD1 | phosphorylation up-regulates → | CXCR4 PSer325 | phosphorylation down-regulates ⊣ | CXCR4 | 27127886 | SIGNOR-279263 |
| PRKCD | phosphorylation up-regulates → | CXCR4 PSer325 | phosphorylation down-regulates ⊣ | CXCR4 | 10521508 | SIGNOR-260899 |
| PRKCD | phosphorylation up-regulates → | CXCR4 PSer324 | phosphorylation down-regulates ⊣ | CXCR4 | 10521508 | SIGNOR-260898 |
| PIM3 | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation up-regulates → | CXCR4 | 26075720 | SIGNOR-279092 |
| PRKCD | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation down-regulates ⊣ | CXCR4 | 10521508 | SIGNOR-260901 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK5 | phosphorylation → down-regulates quantity | CXCR4 | SIGNOR-279740 |
| PRKCD | phosphorylation → down-regulates activity | CXCR4 | SIGNOR-260900 |
| PRKD1 | phosphorylation → down-regulates quantity | CXCR4 | SIGNOR-279264 |
| PIM1 | phosphorylation → up-regulates quantity | CXCR4 | SIGNOR-278450 |
| PRKD1 | phosphorylation → down-regulates quantity | CXCR4 | SIGNOR-279263 |
| PRKCD | phosphorylation → down-regulates activity | CXCR4 | SIGNOR-260899 |
| PRKCD | phosphorylation → down-regulates activity | CXCR4 | SIGNOR-260898 |
| PIM3 | phosphorylation → up-regulates quantity | CXCR4 | SIGNOR-279092 |
| PRKCD | phosphorylation → down-regulates activity | CXCR4 | SIGNOR-260901 |
