| Name | HNRNPK |
| ID | P61978 |
| Role | substrate |
| Enzymatic Domains |
KH 1 42-104 PROSITE-ProRule
KH 2 144-209 PROSITE-ProRule
KH 3 387-451 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | HNRNPK | Ser284 | RRDYDDMsPRRGPPP | phosphorylation down-regulates | 16564677 | SIGNOR-145375 |
| SRC | HNRNPK | Tyr230 | QPYDPNFyDETYDYG | phosphorylation down-regulates | 12052863 | SIGNOR-88903 |
| MAPK8 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates activity | 11259409 | SIGNOR-105247 |
| JNK | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates | 11259409 | SIGNOR-105758 |
| MAPK10 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates activity | 11259409 | SIGNOR-250083 |
| MAPK8 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates | 11259409 | SIGNOR-105766 |
| SRC | HNRNPK | Tyr380 | YAGGRGSyGDLGGPI | phosphorylation down-regulates | 12052863 | SIGNOR-88915 |
| SRC | HNRNPK | Tyr234 | PNFYDETyDYGGFTM | phosphorylation down-regulates | 12052863 | SIGNOR-88907 |
| MAPK8 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates activity | 11259409 | SIGNOR-105251 |
| MAPK10 | HNRNPK | Ser284 | RRDYDDMsPRRGPPP | phosphorylation down-regulates activity | 11231586 | SIGNOR-250082 |
| SRC | HNRNPK | Tyr72 | IKALRTDyNASVSVP | phosphorylation down-regulates | 12052863 | SIGNOR-88919 |
| PRKCD | HNRNPK | Ser302 | GRGGRGGsRARNLPL | phosphorylation down-regulates | 10329716 | SIGNOR-67515 |
| MAPK3 | HNRNPK | Ser284 | RRDYDDMsPRRGPPP | phosphorylation down-regulates activity | 11231586 | SIGNOR-105238 |
| MAPK10 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates activity | 11259409 | SIGNOR-250081 |
| SRC | HNRNPK | Tyr236 | FYDETYDyGGFTMMF | phosphorylation down-regulates | 12052863 | SIGNOR-88911 |
| JNK | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105762 |
| PRKCD | HNRNPK | Ser302 | GRGGRGGsRARNLPL | phosphorylation unknown | 10329716 | SIGNOR-260877 |
| ERK1/2 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105754 |
| MAPK8 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105770 |
| SRC | HNRNPK | Tyr225 | IKGRAQPyDPNFYDE | phosphorylation down-regulates | 12052863 | SIGNOR-88899 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | HNRNPK PSer284 | phosphorylation down-regulates ⊣ | HNRNPK | 16564677 | SIGNOR-145375 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr230 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88903 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105247 |
| JNK | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105758 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-250083 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105766 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr380 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88915 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr234 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88907 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105251 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer284 | phosphorylation down-regulates ⊣ | HNRNPK | 11231586 | SIGNOR-250082 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr72 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88919 |
| PRKCD | phosphorylation up-regulates → | HNRNPK PSer302 | phosphorylation down-regulates ⊣ | HNRNPK | 10329716 | SIGNOR-67515 |
| MAPK3 | phosphorylation up-regulates → | HNRNPK PSer284 | phosphorylation down-regulates ⊣ | HNRNPK | 11231586 | SIGNOR-105238 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-250081 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr236 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88911 |
| JNK | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105762 |
| PRKCD | phosphorylation up-regulates → | HNRNPK PSer302 | phosphorylation down-regulates ⊣ | HNRNPK | 10329716 | SIGNOR-260877 |
| ERK1/2 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105754 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105770 |
| SRC | phosphorylation up-regulates → | HNRNPK PTyr225 | phosphorylation down-regulates ⊣ | HNRNPK | 12052863 | SIGNOR-88899 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | HNRNPK | SIGNOR-145375 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88903 |
| MAPK8 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-105247 |
| JNK | phosphorylation → up-regulates | HNRNPK | SIGNOR-105758 |
| MAPK10 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-250083 |
| MAPK8 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105766 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88915 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88907 |
| MAPK8 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-105251 |
| MAPK10 | phosphorylation → down-regulates activity | HNRNPK | SIGNOR-250082 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88919 |
| PRKCD | phosphorylation down-regulates | HNRNPK | SIGNOR-67515 |
| MAPK3 | phosphorylation → down-regulates activity | HNRNPK | SIGNOR-105238 |
| MAPK10 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-250081 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88911 |
| JNK | phosphorylation → up-regulates | HNRNPK | SIGNOR-105762 |
| PRKCD | phosphorylation → unknown | HNRNPK | SIGNOR-260877 |
| ERK1/2 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105754 |
| MAPK8 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105770 |
| SRC | phosphorylation down-regulates | HNRNPK | SIGNOR-88899 |