| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CB | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248569 |
| PPP1CB | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248570 |
| PPP1CB | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248567 |
| PPP1CB | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248568 |
| PPP1CB | AHCYL1 | Ser68 | RSLSRSIsQSSTDSY | dephosphorylation unknown | 17635105 | SIGNOR-248571 |
| PPP1CB | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248572 |
| PPP1CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248573 |
| PPP1CB | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248574 |
| PPP1CB | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163965 |
| PPP1CB | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252604 |
| PPP1CB | NF2 | Ser518 | DTDMKRLsMEIEKEK | dephosphorylation up-regulates | 18071304 | SIGNOR-159836 |
| PPP1CB | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248576 |
| PPP1CB | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248577 |
| PPP1CB | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174862 | |
| PPP1CB | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248575 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248569 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248570 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248567 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248568 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AHCYL1 PSer68 | dephosphorylation up-regulates → | AHCYL1 | 17635105 | SIGNOR-248571 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248572 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248573 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248574 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163965 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252604 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NF2 PSer518 | dephosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159836 |
| PPP1CB | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248576 |
| PPP1CB | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248577 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248575 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248569 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248570 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248567 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248568 |
| PPP1CB | dephosphorylation → unknown | AHCYL1 | SIGNOR-248571 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248572 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248573 |
| PPP1CB | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248574 |
| PPP1CB | dephosphorylation down-regulates | AKT1 | SIGNOR-163965 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252604 |
| PPP1CB | dephosphorylation → up-regulates | NF2 | SIGNOR-159836 |
| PPP1CB | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248576 |
| PPP1CB | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248577 |
| PPP1CB | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174862 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT | SIGNOR-248575 |
