| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248579 |
| PPP2CB | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248578 |
| PPP2CB | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248581 |
| PPP2CB | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248580 |
| PPP2CB | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248582 |
| PPP2CB | MYC | Ser62 | LLPTPPLsPSRRSGL | dephosphorylation down-regulates | 16987807 | SIGNOR-149726 |
| PPP2CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation up-regulates quantity by stabilization | 14712210 | SIGNOR-248584 |
| PPP2CB | TP53 | Thr55 | DDIEQWFtEDPGPDE | dephosphorylation up-regulates quantity by stabilization | 17245430 | SIGNOR-248583 |
| PPP2CB | PRKCB | Thr500 | WDGVTTKtFCGTPDY | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248585 |
| PPP2CB | PRKCB | Ser660 | QSEFEGFsFVNSEFL | dephosphorylation down-regulates activity | 15880462 | SIGNOR-248586 |
| PPP2CB | PRKCB | Thr641 | TRHPPVLtPPDQEVI | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248587 |
| PPP2CB | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248588 |
| PPP2CB | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248589 |
| PPP2CB | RALA | Ser183 | RARKMEDsKEKNGKK | dephosphorylation down-regulates | 17540176 | SIGNOR-155349 |
| PPP2CB | RALA | Ser194 | NGKKKRKsLAKRIRE | dephosphorylation down-regulates | 17540176 | SIGNOR-155353 |
| PPP2CB | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248590 |
| PPP2CB | AKT1 | – | dephosphorylation down-regulates | 8650155 | SIGNOR-252636 | |
| PPP2CB | AKT2 | – | dephosphorylation down-regulates | 8650155 | SIGNOR-42123 | |
| PPP2CB | ELF1 | Thr231 | CPKYIKWtQREKGIF | dephosphorylation down-regulates activity | 18714041 | SIGNOR-248591 |
| PPP2CB | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248592 |
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates | 11983168 | SIGNOR-86736 |
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248593 |
| PPP2CB | PRKCD | Ser645 | LNEKARLsYSDKNLI | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248595 |
| PPP2CB | PRKCD | Ser664 | QSAFAGFsFVNPKFE | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248596 |
| PPP2CB | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248594 |
| PPP2CB | TRAF2 | Thr117 | DGCTWKGtLKEYESC | dephosphorylation down-regulates activity | 17188031 | SIGNOR-248597 |
| PPP2CB | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248599 |
| PPP2CB | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248598 |
| PPP2CB | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248600 |
| PPP2CB | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248601 |
| PPP2CB | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248602 |
| PPP2CB | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248603 |
| PPP2CB | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248604 |
| PPP2CB | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248605 |
| PPP2CB | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248606 |
| PPP2CB | CARD11 | Ser644 | NLMFRKFsLERPFRP | dephosphorylation down-regulates activity | 21157432 | SIGNOR-248607 |
| PPP2CB | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248610 |
| PPP2CB | AKT3 | Ser474 | HFPQFSYsASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248609 |
| PPP2CB | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248611 |
| PPP2CB | AKT3 | Thr309 | TMKTFCGtPEYLAPE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248612 |
| PPP2CB | AKT | – | dephosphorylation down-regulates | 8650155 | SIGNOR-42050 | |
| PPP2CB | AKT | – | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248614 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248579 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248578 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248581 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248580 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248582 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MYC PSer62 | dephosphorylation up-regulates → | MYC | 16987807 | SIGNOR-149726 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation down-regulates ⊣ | TP53 | 14712210 | SIGNOR-248584 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TP53 PThr55 | dephosphorylation down-regulates ⊣ | TP53 | 17245430 | SIGNOR-248583 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCB PThr500 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248585 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCB PSer660 | dephosphorylation up-regulates → | PRKCB | 15880462 | SIGNOR-248586 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCB PThr641 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248587 |
| PPP2CB | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248588 |
| PPP2CB | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248589 |
| PPP2CB | dephosphorylation down-regulates ⊣ | RALA PSer183 | dephosphorylation up-regulates → | RALA | 17540176 | SIGNOR-155349 |
| PPP2CB | dephosphorylation down-regulates ⊣ | RALA PSer194 | dephosphorylation up-regulates → | RALA | 17540176 | SIGNOR-155353 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248590 |
| PPP2CB | dephosphorylation down-regulates ⊣ | ELF1 PThr231 | dephosphorylation up-regulates → | ELF1 | 18714041 | SIGNOR-248591 |
| PPP2CB | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248592 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-86736 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248593 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PSer645 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248595 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PSer664 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248596 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248594 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TRAF2 PThr117 | dephosphorylation up-regulates → | TRAF2 | 17188031 | SIGNOR-248597 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248599 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248598 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248600 |
| PPP2CB | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248601 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248602 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer155 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248603 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248604 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248605 |
| PPP2CB | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248606 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CARD11 PSer644 | dephosphorylation up-regulates → | CARD11 | 21157432 | SIGNOR-248607 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248610 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PSer474 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248609 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248611 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PThr309 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248612 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248579 |
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248578 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248581 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248580 |
| PPP2CB | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248582 |
| PPP2CB | dephosphorylation down-regulates | MYC | SIGNOR-149726 |
| PPP2CB | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248584 |
| PPP2CB | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248583 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248585 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248586 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248587 |
| PPP2CB | dephosphorylation → unknown | KRT8 | SIGNOR-248588 |
| PPP2CB | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248589 |
| PPP2CB | dephosphorylation down-regulates | RALA | SIGNOR-155349 |
| PPP2CB | dephosphorylation down-regulates | RALA | SIGNOR-155353 |
| PPP2CB | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248590 |
| PPP2CB | dephosphorylation down-regulates | AKT1 | SIGNOR-252636 |
| PPP2CB | dephosphorylation down-regulates | AKT2 | SIGNOR-42123 |
| PPP2CB | dephosphorylation → down-regulates activity | ELF1 | SIGNOR-248591 |
| PPP2CB | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248592 |
| PPP2CB | dephosphorylation → up-regulates | MDM2 | SIGNOR-86736 |
| PPP2CB | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248593 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248595 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248596 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248594 |
| PPP2CB | dephosphorylation → down-regulates activity | TRAF2 | SIGNOR-248597 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248599 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248598 |
| PPP2CB | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248600 |
| PPP2CB | dephosphorylation → down-regulates activity | ATM | SIGNOR-248601 |
| PPP2CB | dephosphorylation → unknown | PPP1R1A | SIGNOR-248602 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248603 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248604 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248605 |
| PPP2CB | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248606 |
| PPP2CB | dephosphorylation → down-regulates activity | CARD11 | SIGNOR-248607 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248610 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248609 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248611 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248612 |
| PPP2CB | dephosphorylation down-regulates | AKT | SIGNOR-42050 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT | SIGNOR-248614 |
