| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | RHOB | Thr175 | REVFETAtRAALQKR | phosphorylation up-regulates activity | 30297842 | SIGNOR-279728 |
| CSNK1A1 | RHOB | Ser185 | ALQKRYGsQNGCINC | phosphorylation down-regulates | 18590726 | SIGNOR-179255 |
| CHEK1 | RHOB | Thr173 | GVREVFEtATRAALQ | phosphorylation up-regulates activity | 30297842 | SIGNOR-279727 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | RHOB PThr175 | phosphorylation up-regulates → | RHOB | 30297842 | SIGNOR-279728 |
| CSNK1A1 | phosphorylation up-regulates → | RHOB PSer185 | phosphorylation down-regulates ⊣ | RHOB | 18590726 | SIGNOR-179255 |
| CHEK1 | phosphorylation up-regulates → | RHOB PThr173 | phosphorylation up-regulates → | RHOB | 30297842 | SIGNOR-279727 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | RHOB | SIGNOR-279728 |
| CSNK1A1 | phosphorylation![]() down-regulates | RHOB | SIGNOR-179255 |
| CHEK1 | phosphorylation → up-regulates activity | RHOB | SIGNOR-279727 |