| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK4 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation unknown | 20805321 | SIGNOR-167671 |
| PAK4 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation up-regulates | 20805321 | SIGNOR-167667 |
| PLK1 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation up-regulates | 16930555 | SIGNOR-149073 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK4 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation down-regulates ⊣ | RAN | 20805321 | SIGNOR-167671 |
| PAK4 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation up-regulates → | RAN | 20805321 | SIGNOR-167667 |
| PLK1 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation up-regulates → | RAN | 16930555 | SIGNOR-149073 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK4 | phosphorylation → unknown | RAN | SIGNOR-167671 |
| PAK4 | phosphorylation → up-regulates | RAN | SIGNOR-167667 |
| PLK1 | phosphorylation → up-regulates | RAN | SIGNOR-149073 |
