| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | YWHAZ | Ser184 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15071501 | SIGNOR-124020 |
| PRKCD | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 12861023 | SIGNOR-249222 |
| AKT1 | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation unknown | 11956222 | SIGNOR-116587 |
| CSNK1A1 | YWHAZ | Thr232 | LTLWTSDtQGDEAEA | phosphorylation down-regulates activity | 9360956 | SIGNOR-250796 |
| BCR | YWHAZ | Thr232 | LTLWTSDtQGDEAEA | phosphorylation unknown | 16045749 | SIGNOR-250595 |
| PRKACA | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 16376338 | SIGNOR-143373 |
| AKT | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation unknown | 11956222 | SIGNOR-244381 |
| PIM1 | YWHAZ | Ser64 | SSWRVVSsIEQKTEG | phosphorylation up-regulates activity | 34697370 | SIGNOR-277574 |
| MAPK9 | YWHAZ | Ser184 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15071501 | SIGNOR-124031 |
| MAPKAPK2 | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 12861023 | SIGNOR-250151 |
| MAPK10 | YWHAZ | Ser184 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15071501 | SIGNOR-124009 |
| JNK | YWHAZ | – | phosphorylation down-regulates | 15071501 | SIGNOR-269980 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | YWHAZ PSer184 | phosphorylation down-regulates ⊣ | YWHAZ | 15071501 | SIGNOR-124020 |
| PRKCD | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 12861023 | SIGNOR-249222 |
| AKT1 | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 11956222 | SIGNOR-116587 |
| CSNK1A1 | phosphorylation up-regulates → | YWHAZ PThr232 | phosphorylation down-regulates ⊣ | YWHAZ | 9360956 | SIGNOR-250796 |
| BCR | phosphorylation up-regulates → | YWHAZ PThr232 | phosphorylation down-regulates ⊣ | YWHAZ | 16045749 | SIGNOR-250595 |
| PRKACA | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 16376338 | SIGNOR-143373 |
| AKT | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 11956222 | SIGNOR-244381 |
| PIM1 | phosphorylation up-regulates → | YWHAZ PSer64 | phosphorylation up-regulates → | YWHAZ | 34697370 | SIGNOR-277574 |
| MAPK9 | phosphorylation up-regulates → | YWHAZ PSer184 | phosphorylation down-regulates ⊣ | YWHAZ | 15071501 | SIGNOR-124031 |
| MAPKAPK2 | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 12861023 | SIGNOR-250151 |
| MAPK10 | phosphorylation up-regulates → | YWHAZ PSer184 | phosphorylation down-regulates ⊣ | YWHAZ | 15071501 | SIGNOR-124009 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | YWHAZ | SIGNOR-124020 |
| PRKCD | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-249222 |
| AKT1 | phosphorylation → unknown | YWHAZ | SIGNOR-116587 |
| CSNK1A1 | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-250796 |
| BCR | phosphorylation → unknown | YWHAZ | SIGNOR-250595 |
| PRKACA | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-143373 |
| AKT | phosphorylation → unknown | YWHAZ | SIGNOR-244381 |
| PIM1 | phosphorylation → up-regulates activity | YWHAZ | SIGNOR-277574 |
| MAPK9 | phosphorylation down-regulates | YWHAZ | SIGNOR-124031 |
| MAPKAPK2 | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-250151 |
| MAPK10 | phosphorylation down-regulates | YWHAZ | SIGNOR-124009 |
| JNK | phosphorylation down-regulates | YWHAZ | SIGNOR-269980 |
