| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK2 | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 12861023 | SIGNOR-250151 |
| PRKACA | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 16376338 | SIGNOR-143373 |
| PRKCD | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation down-regulates activity | 12861023 | SIGNOR-249222 |
| AKT1 | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation unknown | 11956222 | SIGNOR-116587 |
| AKT | YWHAZ | Ser58 | VVGARRSsWRVVSSI | phosphorylation unknown | 11956222 | SIGNOR-244381 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK2 | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 12861023 | SIGNOR-250151 |
| PRKACA | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 16376338 | SIGNOR-143373 |
| PRKCD | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 12861023 | SIGNOR-249222 |
| AKT1 | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 11956222 | SIGNOR-116587 |
| AKT | phosphorylation up-regulates → | YWHAZ PSer58 | phosphorylation down-regulates ⊣ | YWHAZ | 11956222 | SIGNOR-244381 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPKAPK2 | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-250151 |
| PRKACA | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-143373 |
| PRKCD | phosphorylation → down-regulates activity | YWHAZ | SIGNOR-249222 |
| AKT1 | phosphorylation → unknown | YWHAZ | SIGNOR-116587 |
| AKT | phosphorylation → unknown | YWHAZ | SIGNOR-244381 |
