| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248616 |
| PPP2CA | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248615 |
| PPP2CA | MAP3K7 | Thr187 | CDIQTHMtNNKGSAA | dephosphorylation down-regulates | 17079228 | SIGNOR-150369 |
| PPP2CA | FOXO3 | Ser253 | APRRRAVsMDNSNKY | dephosphorylation up-regulates | 20110348 | SIGNOR-163680 |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates | 20110348 | SIGNOR-163684 |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates activity | 20110348 | SIGNOR-163688 |
| PPP2CA | PTTG1 | Ser31 | LKLGSGPsIKALDGR | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276379 |
| PPP2CA | PTTG1 | Ser87 | PLKQKQPsFSAKKMT | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276378 |
| PPP2CA | PTTG1 | Ser89 | KQKQPSFsAKKMTEK | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276380 |
| PPP2CA | PTTG1 | Thr66 | ATRKALGtVNRATEK | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276376 |
| PPP2CA | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16596250 | SIGNOR-248617 |
| PPP2CA | RAF1 | – | dephosphorylation up-regulates | 16239230 | SIGNOR-141170 | |
| PPP2CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 14712210 | SIGNOR-248619 |
| PPP2CA | TP53 | Thr55 | DDIEQWFtEDPGPDE | dephosphorylation up-regulates quantity by stabilization | 17245430 | SIGNOR-248618 |
| PPP2CA | PRKCB | Thr500 | WDGVTTKtFCGTPDY | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248620 |
| PPP2CA | PRKCB | Ser660 | QSEFEGFsFVNSEFL | dephosphorylation down-regulates activity | 15880462 | SIGNOR-248621 |
| PPP2CA | PRKCB | Thr641 | TRHPPVLtPPDQEVI | dephosphorylation down-regulates activity | 8749392 | SIGNOR-248622 |
| PPP2CA | KRT8 | Ser432 | SAYGGLTsPGLSYSL | dephosphorylation unknown | 16554440 | SIGNOR-248623 |
| PPP2CA | RB1 | – | dephosphorylation up-regulates | 10702384 | SIGNOR-75398 | |
| PPP2CA | EIF4E | Ser209 | DTATKSGsTTKNRFV | dephosphorylation down-regulates | 20927323 | SIGNOR-168306 |
| PPP2CA | SP1 | Ser59 | GGQESQPsPLALLAA | dephosphorylation up-regulates activity | 24382322 | SIGNOR-248223 |
| PPP2CA | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248624 |
| PPP2CA | SRC | Ser12 | KSKPKDAsQRRRSLE | dephosphorylation down-regulates activity | 18069897 | SIGNOR-247970 |
| PPP2CA | EEF2 | Thr57 | RAGETRFtDTRKDEQ | dephosphorylation up-regulates | 8386634 | SIGNOR-38561 |
| PPP2CA | EEF2 | Thr59 | GETRFTDtRKDEQER | dephosphorylation up-regulates | 8386634 | SIGNOR-38566 |
| PPP2CA | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | dephosphorylation down-regulates | 15769444 | SIGNOR-134597 |
| PPP2CA | TNNI3 | Ser24 | APIRRRSsNYRAYAT | dephosphorylation down-regulates | 15769444 | SIGNOR-134601 |
| PPP2CA | TFEB | Ser109 | NKFAAHIsPAQGSPK | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277881 |
| PPP2CA | TFEB | Ser114 | HISPAQGsPKPPPAA | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277880 |
| PPP2CA | TFEB | Ser122 | PKPPPAAsPGVRAGH | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277878 |
| PPP2CA | TFEB | Ser211 | LVGVTSSsCPADLTQ | dephosphorylation up-regulates activity | 29945972 | SIGNOR-277879 |
| PPP2CA | RPS3 | Ser6 | sKKRKFVA | dephosphorylation down-regulates | 15950189 | SIGNOR-137963 |
| PPP2CA | RPS6KB1 | – | dephosphorylation down-regulates | 2826472 | SIGNOR-23575 | |
| PPP2CA | FCAR | Ser284 | LTFARTPsVCK | dephosphorylation up-regulates activity | 30766540 | SIGNOR-264858 |
| PPP2CA | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103162 | |
| PPP2CA | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-144322 |
| PPP2CA | DCK | Ser74 | EFEELTMsQKNGGNV | dephosphorylation down-regulates activity | 24462681 | SIGNOR-275803 |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-143052 |
| PPP2CA | MAPK1 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166655 | |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103159 |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248625 |
| PPP2CA | RBL1 | – | dephosphorylation up-regulates | 15467457 | SIGNOR-129749 | |
| PPP2CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-252616 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252606 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252614 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248628 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248626 |
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248631 |
| PPP2CA | AKT2 | Thr309 | SDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248633 |
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248632 |
| PPP2CA | AKT2 | Thr309 | SDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248630 |
| PPP2CA | ELF1 | Thr231 | CPKYIKWtQREKGIF | dephosphorylation down-regulates activity | 18714041 | SIGNOR-248634 |
| PPP2CA | CTNNB1 | – | dephosphorylation up-regulates | 19061640 | SIGNOR-182637 | |
| PPP2CA | MAP2K2 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166652 | |
| PPP2CA | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248635 |
| PPP2CA | HDAC4 | Ser298 | ACSSAPGsGPSSPNN | dephosphorylation up-regulates | 18045992 | SIGNOR-159492 |
| PPP2CA | SMAD3 | – | dephosphorylation down-regulates | 19951945 | SIGNOR-161919 | |
| PPP2CA | SMAD3 | – | dephosphorylation down-regulates | 20704570 | SIGNOR-167480 | |
| PPP2CA | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248636 |
| PPP2CA | MAP2K1 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166649 | |
| PPP2CA | RELA | – | dephosphorylation down-regulates | 11591705 | SIGNOR-110959 | |
| PPP2CA | PRKCD | Ser645 | LNEKARLsYSDKNLI | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248638 |
| PPP2CA | PRKCD | Ser664 | QSAFAGFsFVNPKFE | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248639 |
| PPP2CA | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248637 |
| PPP2CA | RBL2 | – | dephosphorylation up-regulates | 15467457 | SIGNOR-129752 | |
| PPP2CA | TFCP2 | Ser291 | TYVNNSPsPGFNSSH | dephosphorylation up-regulates | 20682773 | SIGNOR-167385 |
| PPP2CA | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | dephosphorylation up-regulates | 20682773 | SIGNOR-167389 |
| PPP2CA | TRAF2 | Thr117 | DGCTWKGtLKEYESC | dephosphorylation down-regulates activity | 17188031 | SIGNOR-248640 |
| PPP2CA | STK4 | Thr183 | DTMAKRNtVIGTPFW | dephosphorylation down-regulates | 23431053 | SIGNOR-201270 |
| PPP2CA | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248642 |
| PPP2CA | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248641 |
| PPP2CA | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248643 |
| PPP2CA | STK3 | Thr180 | DTMAKRNtVIGTPFW | dephosphorylation down-regulates | 23431053 | SIGNOR-201266 |
| PPP2CA | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248644 |
| PPP2CA | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-248645 |
| PPP2CA | IRF3 | – | dephosphorylation down-regulates activity | 24726876 | SIGNOR-260944 | |
| PPP2CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277184 |
| PPP2CA | TRPM8 | Ser9 | SFRAARLsMRNRRND | dephosphorylation down-regulates activity | 20110357 | SIGNOR-273794 |
| PPP2CA | TRPM8 | Thr17 | MRNRRNDtLDSTRTL | dephosphorylation down-regulates activity | 20110357 | SIGNOR-273793 |
| PPP2CA | DDHD1 | Ser727 | TIPSPVTsPVLSRRH | dephosphorylation unknown | 11328814 | SIGNOR-262976 |
| PPP2CA | DDHD1 | Ser711 | NPAKEPTsVSENEGI | dephosphorylation up-regulates activity | 11328814 | SIGNOR-262975 |
| PPP2CA | MAPK15 | Thr175 | GPEDQAVtEYVATRW | dephosphorylation down-regulates | 16336213 | SIGNOR-142977 |
| PPP2CA | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248646 |
| PPP2CA | HDAC7 | Ser181 | NPLLRKEsAPPSLRR | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248647 |
| PPP2CA | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248648 |
| PPP2CA | HDAC7 | Ser486 | RPLSRAQsSPAAPAS | dephosphorylation up-regulates activity | 18339811 | SIGNOR-248649 |
| PPP2CA | HDAC2 | Ser394 | EDAVHEDsGDEDGED | dephosphorylation down-regulates activity | 30050113 | SIGNOR-277049 |
| PPP2CA | MAP3K3 | Ser520 | RLQTICMsGTGMRSV | dephosphorylation down-regulates | 20448038 | SIGNOR-165229 |
| PPP2CA | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | dephosphorylation down-regulates | 20448038 | SIGNOR-165233 |
| PPP2CA | MAP3K3 | Thr516 | GASKRLQtICMSGTG | dephosphorylation down-regulates | 20448038 | SIGNOR-165237 |
| PPP2CA | MKNK1 | Thr250 | NSCTPITtPELTTPC | dephosphorylation down-regulates | 20927323 | SIGNOR-168310 |
| PPP2CA | MKNK1 | Thr255 | ITTPELTtPCGSAEY | dephosphorylation down-regulates | 20927323 | SIGNOR-168314 |
| PPP2CA | CARD11 | Ser644 | NLMFRKFsLERPFRP | dephosphorylation down-regulates activity | 21157432 | SIGNOR-248650 |
| PPP2CA | RACGAP1 | Ser387 | ETGLYRIsGCDRTVK | dephosphorylation down-regulates | 18201571 | SIGNOR-160398 |
| PPP2CA | RACGAP1 | Thr588 | PEHQLLKtPSSSSLS | dephosphorylation down-regulates | 18201571 | SIGNOR-160402 |
| PPP2CA | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates | 15988018 | SIGNOR-138428 |
| PPP2CA | CILK1 | Tyr159 | SKPPYTDyVSTRWYR | dephosphorylation down-regulates | 15988018 | SIGNOR-138432 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248652 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248654 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248653 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248651 |
| PPP2CA | NfKb-p65/p50 | – | dephosphorylation down-regulates | 11591705 | SIGNOR-217421 | |
| PPP2CA | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269918 | |
| PPP2CA | AKT | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-114767 |
| PPP2CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248627 |
| PPP2CA | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248629 |
| PPP2CA | AKT | – | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248655 | |
| PPP2CA | MEK1/2 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-244941 | |
| PPP2CA | FOXO | Ser253 | APRRRAVsMDNSNKY | dephosphorylation up-regulates | 18593906 | SIGNOR-252971 |
| PPP2CA | FOXO | Ser253 | APRRRAVsMDNSNKY | dephosphorylation up-regulates | 20110348 | SIGNOR-252973 |
| PPP2CA | FOXO | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates | 20110348 | SIGNOR-252974 |
| PPP2CA | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269896 | |
| PPP2CA | STK3/4 | – | dephosphorylation down-regulates | 23431053 | SIGNOR-269940 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248616 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248615 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K7 PThr187 | dephosphorylation up-regulates → | MAP3K7 | 17079228 | SIGNOR-150369 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PSer253 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163680 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163684 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163688 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer31 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276379 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer87 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276378 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer89 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276380 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PThr66 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276376 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16596250 | SIGNOR-248617 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 14712210 | SIGNOR-248619 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TP53 PThr55 | dephosphorylation down-regulates ⊣ | TP53 | 17245430 | SIGNOR-248618 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCB PThr500 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248620 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCB PSer660 | dephosphorylation up-regulates → | PRKCB | 15880462 | SIGNOR-248621 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCB PThr641 | dephosphorylation up-regulates → | PRKCB | 8749392 | SIGNOR-248622 |
| PPP2CA | dephosphorylation down-regulates ⊣ | KRT8 PSer432 | dephosphorylation up-regulates → | KRT8 | 16554440 | SIGNOR-248623 |
| PPP2CA | dephosphorylation down-regulates ⊣ | EIF4E PSer209 | dephosphorylation up-regulates → | EIF4E | 20927323 | SIGNOR-168306 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SP1 PSer59 | dephosphorylation down-regulates ⊣ | SP1 | 24382322 | SIGNOR-248223 |
| PPP2CA | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248624 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SRC PSer12 | dephosphorylation up-regulates → | SRC | 18069897 | SIGNOR-247970 |
| PPP2CA | dephosphorylation down-regulates ⊣ | EEF2 PThr57 | dephosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38561 |
| PPP2CA | dephosphorylation down-regulates ⊣ | EEF2 PThr59 | dephosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38566 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TNNI3 PSer23 | dephosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134597 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TNNI3 PSer24 | dephosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134601 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer109 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277881 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer114 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277880 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer122 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277878 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFEB PSer211 | dephosphorylation down-regulates ⊣ | TFEB | 29945972 | SIGNOR-277879 |
| PPP2CA | dephosphorylation down-regulates ⊣ | RPS3 PSer6 | dephosphorylation up-regulates → | RPS3 | 15950189 | SIGNOR-137963 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FCAR PSer284 | dephosphorylation down-regulates ⊣ | FCAR | 30766540 | SIGNOR-264858 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 16456541 | SIGNOR-144322 |
| PPP2CA | dephosphorylation down-regulates ⊣ | DCK PSer74 | dephosphorylation up-regulates → | DCK | 24462681 | SIGNOR-275803 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 16456541 | SIGNOR-143052 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 12840032 | SIGNOR-103159 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248625 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 11839802 | SIGNOR-252616 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252606 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252614 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248628 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248626 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 15367694 | SIGNOR-248631 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PThr309 | dephosphorylation up-regulates → | AKT2 | 15367694 | SIGNOR-248633 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 18160256 | SIGNOR-248632 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PThr309 | dephosphorylation up-regulates → | AKT2 | 18160256 | SIGNOR-248630 |
| PPP2CA | dephosphorylation down-regulates ⊣ | ELF1 PThr231 | dephosphorylation up-regulates → | ELF1 | 18714041 | SIGNOR-248634 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248635 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC4 PSer298 | dephosphorylation down-regulates ⊣ | HDAC4 | 18045992 | SIGNOR-159492 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248636 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PSer645 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248638 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PSer664 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248639 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248637 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFCP2 PSer291 | dephosphorylation down-regulates ⊣ | TFCP2 | 20682773 | SIGNOR-167385 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TFCP2 PSer309 | dephosphorylation down-regulates ⊣ | TFCP2 | 20682773 | SIGNOR-167389 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TRAF2 PThr117 | dephosphorylation up-regulates → | TRAF2 | 17188031 | SIGNOR-248640 |
| PPP2CA | dephosphorylation down-regulates ⊣ | STK4 PThr183 | dephosphorylation up-regulates → | STK4 | 23431053 | SIGNOR-201270 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248642 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248641 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248643 |
| PPP2CA | dephosphorylation down-regulates ⊣ | STK3 PThr180 | dephosphorylation up-regulates → | STK3 | 23431053 | SIGNOR-201266 |
| PPP2CA | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248644 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-248645 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277184 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TRPM8 PSer9 | dephosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273794 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TRPM8 PThr17 | dephosphorylation up-regulates → | TRPM8 | 20110357 | SIGNOR-273793 |
| PPP2CA | dephosphorylation down-regulates ⊣ | DDHD1 PSer727 | dephosphorylation up-regulates → | DDHD1 | 11328814 | SIGNOR-262976 |
| PPP2CA | dephosphorylation down-regulates ⊣ | DDHD1 PSer711 | dephosphorylation down-regulates ⊣ | DDHD1 | 11328814 | SIGNOR-262975 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK15 PThr175 | dephosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142977 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer155 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248646 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer181 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248647 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer358 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248648 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC7 PSer486 | dephosphorylation down-regulates ⊣ | HDAC7 | 18339811 | SIGNOR-248649 |
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC2 PSer394 | dephosphorylation up-regulates → | HDAC2 | 30050113 | SIGNOR-277049 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PSer520 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165229 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PSer526 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165233 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PThr516 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165237 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MKNK1 PThr250 | dephosphorylation up-regulates → | MKNK1 | 20927323 | SIGNOR-168310 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MKNK1 PThr255 | dephosphorylation up-regulates → | MKNK1 | 20927323 | SIGNOR-168314 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CARD11 PSer644 | dephosphorylation up-regulates → | CARD11 | 21157432 | SIGNOR-248650 |
| PPP2CA | dephosphorylation down-regulates ⊣ | RACGAP1 PSer387 | dephosphorylation up-regulates → | RACGAP1 | 18201571 | SIGNOR-160398 |
| PPP2CA | dephosphorylation down-regulates ⊣ | RACGAP1 PThr588 | dephosphorylation up-regulates → | RACGAP1 | 18201571 | SIGNOR-160402 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138428 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PTyr159 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138432 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248652 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248654 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248653 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248651 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr450 | dephosphorylation up-regulates → | AKT | 11839802 | SIGNOR-114767 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248627 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 15367694 | SIGNOR-248629 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO PSer253 | dephosphorylation down-regulates ⊣ | FOXO | 18593906 | SIGNOR-252971 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO PSer253 | dephosphorylation down-regulates ⊣ | FOXO | 20110348 | SIGNOR-252973 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO PThr32 | dephosphorylation down-regulates ⊣ | FOXO | 20110348 | SIGNOR-252974 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248616 |
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248615 |
| PPP2CA | dephosphorylation down-regulates | MAP3K7 | SIGNOR-150369 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163680 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163684 |
| PPP2CA | dephosphorylation → up-regulates activity | FOXO3 | SIGNOR-163688 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276379 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276378 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276380 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276376 |
| PPP2CA | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248617 |
| PPP2CA | dephosphorylation → up-regulates | RAF1 | SIGNOR-141170 |
| PPP2CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248619 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248618 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248620 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248621 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCB | SIGNOR-248622 |
| PPP2CA | dephosphorylation → unknown | KRT8 | SIGNOR-248623 |
| PPP2CA | dephosphorylation → up-regulates | RB1 | SIGNOR-75398 |
| PPP2CA | dephosphorylation down-regulates | EIF4E | SIGNOR-168306 |
| PPP2CA | dephosphorylation → up-regulates activity | SP1 | SIGNOR-248223 |
| PPP2CA | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248624 |
| PPP2CA | dephosphorylation → down-regulates activity | SRC | SIGNOR-247970 |
| PPP2CA | dephosphorylation → up-regulates | EEF2 | SIGNOR-38561 |
| PPP2CA | dephosphorylation → up-regulates | EEF2 | SIGNOR-38566 |
| PPP2CA | dephosphorylation down-regulates | TNNI3 | SIGNOR-134597 |
| PPP2CA | dephosphorylation down-regulates | TNNI3 | SIGNOR-134601 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277881 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277880 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277878 |
| PPP2CA | dephosphorylation → up-regulates activity | TFEB | SIGNOR-277879 |
| PPP2CA | dephosphorylation down-regulates | RPS3 | SIGNOR-137963 |
| PPP2CA | dephosphorylation down-regulates | RPS6KB1 | SIGNOR-23575 |
| PPP2CA | dephosphorylation → up-regulates activity | FCAR | SIGNOR-264858 |
| PPP2CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-103162 |
| PPP2CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-144322 |
| PPP2CA | dephosphorylation → down-regulates activity | DCK | SIGNOR-275803 |
| PPP2CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-143052 |
| PPP2CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-166655 |
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-103159 |
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248625 |
| PPP2CA | dephosphorylation → up-regulates | RBL1 | SIGNOR-129749 |
| PPP2CA | dephosphorylation down-regulates | AKT1 | SIGNOR-252616 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252606 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252614 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248628 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248626 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248631 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248633 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248632 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248630 |
| PPP2CA | dephosphorylation → down-regulates activity | ELF1 | SIGNOR-248634 |
| PPP2CA | dephosphorylation → up-regulates | CTNNB1 | SIGNOR-182637 |
| PPP2CA | dephosphorylation down-regulates | MAP2K2 | SIGNOR-166652 |
| PPP2CA | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248635 |
| PPP2CA | dephosphorylation → up-regulates | HDAC4 | SIGNOR-159492 |
| PPP2CA | dephosphorylation down-regulates | SMAD3 | SIGNOR-161919 |
| PPP2CA | dephosphorylation down-regulates | SMAD3 | SIGNOR-167480 |
| PPP2CA | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248636 |
| PPP2CA | dephosphorylation down-regulates | MAP2K1 | SIGNOR-166649 |
| PPP2CA | dephosphorylation down-regulates | RELA | SIGNOR-110959 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248638 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248639 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248637 |
| PPP2CA | dephosphorylation → up-regulates | RBL2 | SIGNOR-129752 |
| PPP2CA | dephosphorylation → up-regulates | TFCP2 | SIGNOR-167385 |
| PPP2CA | dephosphorylation → up-regulates | TFCP2 | SIGNOR-167389 |
| PPP2CA | dephosphorylation → down-regulates activity | TRAF2 | SIGNOR-248640 |
| PPP2CA | dephosphorylation down-regulates | STK4 | SIGNOR-201270 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248642 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248641 |
| PPP2CA | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248643 |
| PPP2CA | dephosphorylation down-regulates | STK3 | SIGNOR-201266 |
| PPP2CA | dephosphorylation → down-regulates activity | ATM | SIGNOR-248644 |
| PPP2CA | dephosphorylation → unknown | PPP1R1A | SIGNOR-248645 |
| PPP2CA | dephosphorylation → down-regulates activity | IRF3 | SIGNOR-260944 |
| PPP2CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277184 |
| PPP2CA | dephosphorylation → down-regulates activity | TRPM8 | SIGNOR-273794 |
| PPP2CA | dephosphorylation → down-regulates activity | TRPM8 | SIGNOR-273793 |
| PPP2CA | dephosphorylation → unknown | DDHD1 | SIGNOR-262976 |
| PPP2CA | dephosphorylation → up-regulates activity | DDHD1 | SIGNOR-262975 |
| PPP2CA | dephosphorylation down-regulates | MAPK15 | SIGNOR-142977 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248646 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248647 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248648 |
| PPP2CA | dephosphorylation → up-regulates activity | HDAC7 | SIGNOR-248649 |
| PPP2CA | dephosphorylation → down-regulates activity | HDAC2 | SIGNOR-277049 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165229 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165233 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165237 |
| PPP2CA | dephosphorylation down-regulates | MKNK1 | SIGNOR-168310 |
| PPP2CA | dephosphorylation down-regulates | MKNK1 | SIGNOR-168314 |
| PPP2CA | dephosphorylation → down-regulates activity | CARD11 | SIGNOR-248650 |
| PPP2CA | dephosphorylation down-regulates | RACGAP1 | SIGNOR-160398 |
| PPP2CA | dephosphorylation down-regulates | RACGAP1 | SIGNOR-160402 |
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138428 |
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138432 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248652 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248654 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248653 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248651 |
| PPP2CA | dephosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217421 |
| PPP2CA | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269918 |
| PPP2CA | dephosphorylation down-regulates | AKT | SIGNOR-114767 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248627 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248629 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248655 |
| PPP2CA | dephosphorylation down-regulates | MEK1/2 | SIGNOR-244941 |
| PPP2CA | dephosphorylation → up-regulates | FOXO | SIGNOR-252971 |
| PPP2CA | dephosphorylation → up-regulates | FOXO | SIGNOR-252973 |
| PPP2CA | dephosphorylation → up-regulates | FOXO | SIGNOR-252974 |
| PPP2CA | dephosphorylation down-regulates | Gbeta | SIGNOR-269896 |
| PPP2CA | dephosphorylation down-regulates | STK3/4 | SIGNOR-269940 |
