Entity Details

Name SH3BP2
ID P78314
Role substrate
Enzymatic Domains
PH 26-130
PROSITE-ProRule
SH2 457-555
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SYKSH3BP2Tyr183HDDEDDSyLEPDSPEphosphorylation
up-regulates activity		12709437SIGNOR-246592
PTPN6SH3BP2Tyr448GDDSDEDyEKVPLPNdephosphorylation
down-regulates activity		16649996SIGNOR-277172
SYKSH3BP2Tyr448GDDSDEDyEKVPLPNphosphorylation
up-regulates activity		12709437SIGNOR-246596
SYKSH3BP2Tyr174YPTDNEDyEHDDEDDphosphorylation
up-regulates activity		12709437SIGNOR-246587
PTPN6SH3BP2–dephosphorylation
down-regulates		16649996SIGNOR-146508
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SYKphosphorylation
up-regulates
→
SH3BP2
PTyr183		phosphorylation
up-regulates
→		SH3BP212709437SIGNOR-246592
PTPN6dephosphorylation
down-regulates
⊣
SH3BP2
PTyr448		dephosphorylation
up-regulates
→		SH3BP216649996SIGNOR-277172
SYKphosphorylation
up-regulates
→
SH3BP2
PTyr448		phosphorylation
up-regulates
→		SH3BP212709437SIGNOR-246596
SYKphosphorylation
up-regulates
→
SH3BP2
PTyr174		phosphorylation
up-regulates
→		SH3BP212709437SIGNOR-246587
Regulator Mechanism/Effect Target SIGNOR-ID
SYKphosphorylation
→
up-regulates activity 		SH3BP2SIGNOR-246592
PTPN6dephosphorylation
→
down-regulates activity 		SH3BP2SIGNOR-277172
SYKphosphorylation
→
up-regulates activity 		SH3BP2SIGNOR-246596
SYKphosphorylation
→
up-regulates activity 		SH3BP2SIGNOR-246587
PTPN6dephosphorylation
img/direct_inhibition.png
down-regulates 		SH3BP2SIGNOR-146508