| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | SH3BP2 | Tyr448 | GDDSDEDyEKVPLPN | dephosphorylation down-regulates activity | 16649996 | SIGNOR-277172 |
| SYK | SH3BP2 | Tyr448 | GDDSDEDyEKVPLPN | phosphorylation up-regulates activity | 12709437 | SIGNOR-246596 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | SH3BP2 PTyr448 | dephosphorylation up-regulates → | SH3BP2 | 16649996 | SIGNOR-277172 |
| SYK | phosphorylation up-regulates → | SH3BP2 PTyr448 | phosphorylation up-regulates → | SH3BP2 | 12709437 | SIGNOR-246596 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | SH3BP2 | SIGNOR-277172 |
| SYK | phosphorylation → up-regulates activity | SH3BP2 | SIGNOR-246596 |
