Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
BTK	GTF2I	Tyr248	EESEDPDyYQYNIQA	phosphorylation up-regulates activity	11373296	SIGNOR-108338
MAPK3	GTF2I	Ser668	INTKALQsPKRPRSP	phosphorylation up-regulates	10648599	SIGNOR-74304
MAPK1	GTF2I	Ser668	INTKALQsPKRPRSP	phosphorylation up-regulates	10648599	SIGNOR-74296
PRKG1	GTF2I	Ser412 View in OncoXplorer	GIPFRRPsTYGIPRL	phosphorylation up-regulates	12082086	SIGNOR-89849
PRKG1	GTF2I	Ser784 View in OncoXplorer	GVPFRRPsTFGIPRL	phosphorylation up-regulates	12082086	SIGNOR-89853
MAPK3	GTF2I	Ser674 View in OncoXplorer	QSPKRPRsPGSNSKV	phosphorylation up-regulates	10648599	SIGNOR-74308
MAPK1	GTF2I	Ser674 View in OncoXplorer	QSPKRPRsPGSNSKV	phosphorylation up-regulates	10648599	SIGNOR-74300
ERK1/2	GTF2I	–		phosphorylation up-regulates	10648599	SIGNOR-270169
SRC	GTF2I	Tyr652	KPELVISyLPPGMAS	phosphorylation up-regulates activity	11934902	SIGNOR-247189
BTK	GTF2I	Tyr398 View in OncoXplorer	QSHVEDLyVEGLPEG	phosphorylation up-regulates activity	11373296	SIGNOR-108342
BTK	GTF2I	Tyr503 View in OncoXplorer	EAHPNDLyVEGLPEN	phosphorylation up-regulates activity	11373296	SIGNOR-108346
Gbeta	GTF2I	–		phosphorylation up-regulates	10648599	SIGNOR-270057
SRC	GTF2I	Tyr248	EESEDPDyYQYNIQA	phosphorylation up-regulates activity	11934902	SIGNOR-247185
JAK2	GTF2I	Tyr248	EESEDPDyYQYNIQA	phosphorylation up-regulates activity	11313464	SIGNOR-235313
BTK	GTF2I	–		phosphorylation up-regulates	9012831	SIGNOR-46060

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
BTK	phosphorylation up-regulates →	GTF2I PTyr248	phosphorylation up-regulates →	GTF2I	11373296	SIGNOR-108338
MAPK3	phosphorylation up-regulates →	GTF2I PSer668	phosphorylation up-regulates →	GTF2I	10648599	SIGNOR-74304
MAPK1	phosphorylation up-regulates →	GTF2I PSer668	phosphorylation up-regulates →	GTF2I	10648599	SIGNOR-74296
PRKG1	phosphorylation up-regulates →	GTF2I PSer412	phosphorylation up-regulates →	GTF2I	12082086	SIGNOR-89849
PRKG1	phosphorylation up-regulates →	GTF2I PSer784	phosphorylation up-regulates →	GTF2I	12082086	SIGNOR-89853
MAPK3	phosphorylation up-regulates →	GTF2I PSer674	phosphorylation up-regulates →	GTF2I	10648599	SIGNOR-74308
MAPK1	phosphorylation up-regulates →	GTF2I PSer674	phosphorylation up-regulates →	GTF2I	10648599	SIGNOR-74300
SRC	phosphorylation up-regulates →	GTF2I PTyr652	phosphorylation up-regulates →	GTF2I	11934902	SIGNOR-247189
BTK	phosphorylation up-regulates →	GTF2I PTyr398	phosphorylation up-regulates →	GTF2I	11373296	SIGNOR-108342
BTK	phosphorylation up-regulates →	GTF2I PTyr503	phosphorylation up-regulates →	GTF2I	11373296	SIGNOR-108346
SRC	phosphorylation up-regulates →	GTF2I PTyr248	phosphorylation up-regulates →	GTF2I	11934902	SIGNOR-247185
JAK2	phosphorylation up-regulates →	GTF2I PTyr248	phosphorylation up-regulates →	GTF2I	11313464	SIGNOR-235313

Regulator	Mechanism/Effect	Target	SIGNOR-ID
BTK	phosphorylation → up-regulates activity	GTF2I	SIGNOR-108338
MAPK3	phosphorylation → up-regulates	GTF2I	SIGNOR-74304
MAPK1	phosphorylation → up-regulates	GTF2I	SIGNOR-74296
PRKG1	phosphorylation → up-regulates	GTF2I	SIGNOR-89849
PRKG1	phosphorylation → up-regulates	GTF2I	SIGNOR-89853
MAPK3	phosphorylation → up-regulates	GTF2I	SIGNOR-74308
MAPK1	phosphorylation → up-regulates	GTF2I	SIGNOR-74300
ERK1/2	phosphorylation → up-regulates	GTF2I	SIGNOR-270169
SRC	phosphorylation → up-regulates activity	GTF2I	SIGNOR-247189
BTK	phosphorylation → up-regulates activity	GTF2I	SIGNOR-108342
BTK	phosphorylation → up-regulates activity	GTF2I	SIGNOR-108346
Gbeta	phosphorylation → up-regulates	GTF2I	SIGNOR-270057
SRC	phosphorylation → up-regulates activity	GTF2I	SIGNOR-247185
JAK2	phosphorylation → up-regulates activity	GTF2I	SIGNOR-235313
BTK	phosphorylation → up-regulates	GTF2I	SIGNOR-46060