| Name | DLG4 |
| ID | P78352 |
| Role | substrate |
| Enzymatic Domains |
PDZ 1 65-151 PROSITE-ProRule
PDZ 2 160-246 PROSITE-ProRule
PDZ 3 313-393 PROSITE-ProRule
SH3 428-498 PROSITE-ProRule
Guanylate kinase-like 534-709 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | DLG4 | Tyr533 | VTQMEVHyARPIIIL | phosphorylation up-regulates activity | 20220006 | SIGNOR-278391 |
| PRKCE | DLG4 | – | phosphorylation up-regulates quantity | 27330081 | SIGNOR-280087 | |
| SRC | DLG4 | Tyr523 | REDSVLSyETVTQME | phosphorylation up-regulates | 24981431 | SIGNOR-205120 |
| EIF2AK3 | DLG4 | Thr19 | YRYQDEDtPPLEHSP | phosphorylation up-regulates activity | 28522733 | SIGNOR-280004 |
| FYN | DLG4 | Tyr523 | REDSVLSyETVTQME | phosphorylation up-regulates | 18721130 | SIGNOR-180449 |
| CDK5 | DLG4 | Ser25 | DTPPLEHsPAHLPNQ | phosphorylation down-regulates activity | 28502042 | SIGNOR-279150 |
| CDK5 | DLG4 | Ser35 | HLPNQANsPPVIVNT | phosphorylation down-regulates activity | 28502042 | SIGNOR-279151 |
| CDK5 | DLG4 | Thr19 | YRYQDEDtPPLEHSP | phosphorylation down-regulates activity | 28502042 | SIGNOR-279152 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | DLG4 PTyr533 | phosphorylation up-regulates → | DLG4 | 20220006 | SIGNOR-278391 |
| SRC | phosphorylation up-regulates → | DLG4 PTyr523 | phosphorylation up-regulates → | DLG4 | 24981431 | SIGNOR-205120 |
| EIF2AK3 | phosphorylation up-regulates → | DLG4 PThr19 | phosphorylation up-regulates → | DLG4 | 28522733 | SIGNOR-280004 |
| FYN | phosphorylation up-regulates → | DLG4 PTyr523 | phosphorylation up-regulates → | DLG4 | 18721130 | SIGNOR-180449 |
| CDK5 | phosphorylation up-regulates → | DLG4 PSer25 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279150 |
| CDK5 | phosphorylation up-regulates → | DLG4 PSer35 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279151 |
| CDK5 | phosphorylation up-regulates → | DLG4 PThr19 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279152 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates activity | DLG4 | SIGNOR-278391 |
| PRKCE | phosphorylation → up-regulates quantity | DLG4 | SIGNOR-280087 |
| SRC | phosphorylation → up-regulates | DLG4 | SIGNOR-205120 |
| EIF2AK3 | phosphorylation → up-regulates activity | DLG4 | SIGNOR-280004 |
| FYN | phosphorylation → up-regulates | DLG4 | SIGNOR-180449 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279150 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279151 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279152 |