| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-252808 |
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-252806 |
| RPS6K | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-252815 |
| AKT1 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 12588998 | SIGNOR-98285 |
| RPS6KA1 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119221 |
| AURKB | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 14583461 | SIGNOR-118890 |
| CHEK1 | H3-3A | Thr12 | KQTARKStGGKAPRK | phosphorylation down-regulates activity | 18243098 | SIGNOR-160557 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70440 |
| RPS6KA3 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70432 |
| ERK1/2 | H3-3A | Ser29 | ATKAARKsAPSTGGV | phosphorylation down-regulates activity | 11278789 | SIGNOR-263068 |
| CKM complex | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273172 |
| MAPK14 | H3-3A | – | phosphorylation unknown | 10806218 | SIGNOR-77224 | |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138479 |
| RPS6KA1 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70428 |
| RPS6KA3 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138471 |
| AURKB | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 10464286 | SIGNOR-70420 |
| PRKACA | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 10464286 | SIGNOR-70424 |
| RPS6KA1 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138467 |
| CDK8 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273173 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 18508628 | SIGNOR-178704 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119233 |
| AURKB | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 12588998 | SIGNOR-98293 |
| RPS6KA5 | H3-3A | Ser29 | ATKAARKsAPSTGGV | phosphorylation down-regulates activity | 18508628 | SIGNOR-178708 |
| FYN | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15537652 | SIGNOR-130274 |
| RPS6KA3 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119225 |
| AKT | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 12588998 | SIGNOR-244275 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-252808 |
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-252806 |
| RPS6K | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-252815 |
| AKT1 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 12588998 | SIGNOR-98285 |
| RPS6KA1 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-119221 |
| AURKB | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 14583461 | SIGNOR-118890 |
| CHEK1 | phosphorylation up-regulates → | H3-3A PThr12 | phosphorylation down-regulates ⊣ | H3-3A | 18243098 | SIGNOR-160557 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-70440 |
| RPS6KA3 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-70432 |
| ERK1/2 | phosphorylation up-regulates → | H3-3A PSer29 | phosphorylation down-regulates ⊣ | H3-3A | 11278789 | SIGNOR-263068 |
| CKM complex | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 18418385 | SIGNOR-273172 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-138479 |
| RPS6KA1 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-70428 |
| RPS6KA3 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-138471 |
| AURKB | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 10464286 | SIGNOR-70420 |
| PRKACA | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 10464286 | SIGNOR-70424 |
| RPS6KA1 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-138467 |
| CDK8 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 18418385 | SIGNOR-273173 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 18508628 | SIGNOR-178704 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-119233 |
| AURKB | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 12588998 | SIGNOR-98293 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer29 | phosphorylation down-regulates ⊣ | H3-3A | 18508628 | SIGNOR-178708 |
| FYN | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15537652 | SIGNOR-130274 |
| RPS6KA3 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-119225 |
| AKT | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 12588998 | SIGNOR-244275 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252808 |
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252806 |
| RPS6K | phosphorylation → down-regulates activity | H3-3A | SIGNOR-252815 |
| AKT1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-98285 |
| RPS6KA1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-119221 |
| AURKB | phosphorylation → up-regulates activity | H3-3A | SIGNOR-118890 |
| CHEK1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-160557 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-70440 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-70432 |
| ERK1/2 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-263068 |
| CKM complex | phosphorylation → down-regulates activity | H3-3A | SIGNOR-273172 |
| MAPK14 | phosphorylation → unknown | H3-3A | SIGNOR-77224 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-138479 |
| RPS6KA1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-70428 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-138471 |
| AURKB | phosphorylation → up-regulates activity | H3-3A | SIGNOR-70420 |
| PRKACA | phosphorylation → up-regulates activity | H3-3A | SIGNOR-70424 |
| RPS6KA1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-138467 |
| CDK8 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-273173 |
| RPS6KA5 | phosphorylation → up-regulates activity | H3-3A | SIGNOR-178704 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-119233 |
| AURKB | phosphorylation → up-regulates activity | H3-3A | SIGNOR-98293 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-178708 |
| FYN | phosphorylation → down-regulates activity | H3-3A | SIGNOR-130274 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-119225 |
| AKT | phosphorylation → down-regulates activity | H3-3A | SIGNOR-244275 |
