| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | FOXO4 | – | phosphorylation up-regulates | 17900900 | SIGNOR-216484 | |
| CSNK1A1 | FOXO4 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183664 | |
| STK4 | FOXO4 | – | phosphorylation up-regulates | 18394876 | SIGNOR-178193 | |
| JNK | FOXO4 | Ser230 | PEGATPTsPVGHFAK | phosphorylation up-regulates | 20959475 | SIGNOR-168754 |
| AKT1 | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates | 16272144 | SIGNOR-252485 |
| DYRK1A | FOXO4 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183677 | |
| RALA | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates activity | 11689711 | SIGNOR-248003 |
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 16272144 | SIGNOR-248055 |
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 11313479 | SIGNOR-251491 |
| CSNK1A1 | FOXO4 | Ser268 | SSNASSVsTRLSPLR | phosphorylation down-regulates quantity by destabilization | 28945225 | SIGNOR-277326 |
| AKT | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates | 16272144 | SIGNOR-141420 |
| MAPK8 | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 15538382 | SIGNOR-130381 |
| MAPK8 | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 15538382 | SIGNOR-130385 |
| AKT1 | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-252568 |
| AKT1 | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates activity | 10217147 | SIGNOR-252569 |
| AKT1 | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-252484 |
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-251477 |
| AKT1 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-252486 |
| AKT1 | FOXO4 | – | phosphorylation down-regulates | 21620960 | SIGNOR-252515 | |
| JNK | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 20959475 | SIGNOR-168766 |
| JNK | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 20959475 | SIGNOR-168762 |
| AKT2 | FOXO4 | – | phosphorylation down-regulates activity | 21620960 | SIGNOR-233529 | |
| AKT | FOXO4 | Ser262 | TFRPRSSsNASSVST | phosphorylation down-regulates activity | 10217147 | SIGNOR-251478 |
| AKT1 | FOXO4 | – | phosphorylation down-regulates | 21798082 | SIGNOR-175291 | |
| CDK2 | FOXO4 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183655 | |
| JNK | FOXO4 | Thr227 | PAPPEGAtPTSPVGH | phosphorylation up-regulates | 20959475 | SIGNOR-168758 |
| RALA | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates activity | 11689711 | SIGNOR-249665 |
| AKT | FOXO4 | – | phosphorylation down-regulates | 21620960 | SIGNOR-174021 | |
| CSNK1A1 | FOXO4 | Ser265 | PRSSSNAsSVSTRLS | phosphorylation down-regulates quantity by destabilization | 28945225 | SIGNOR-277325 |
| PRKAA1 | FOXO4 | – | phosphorylation up-regulates | 17900900 | SIGNOR-157947 | |
| AKT | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-141424 |
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-141416 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | phosphorylation up-regulates → | FOXO4 PSer230 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168754 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-252485 |
| RALA | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 11689711 | SIGNOR-248003 |
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-248055 |
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 11313479 | SIGNOR-251491 |
| CSNK1A1 | phosphorylation up-regulates → | FOXO4 PSer268 | phosphorylation down-regulates ⊣ | FOXO4 | 28945225 | SIGNOR-277326 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141420 |
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130381 |
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130385 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-252568 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-252569 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-252484 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-251477 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-252486 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168766 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168762 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer262 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-251478 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr227 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168758 |
| RALA | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 11689711 | SIGNOR-249665 |
| CSNK1A1 | phosphorylation up-regulates → | FOXO4 PSer265 | phosphorylation down-regulates ⊣ | FOXO4 | 28945225 | SIGNOR-277325 |
| AKT | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141424 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141416 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates | FOXO4 | SIGNOR-216484 |
| CSNK1A1 | phosphorylation down-regulates | FOXO4 | SIGNOR-183664 |
| STK4 | phosphorylation → up-regulates | FOXO4 | SIGNOR-178193 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168754 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-252485 |
| DYRK1A | phosphorylation down-regulates | FOXO4 | SIGNOR-183677 |
| RALA | phosphorylation → up-regulates activity | FOXO4 | SIGNOR-248003 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-248055 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251491 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | FOXO4 | SIGNOR-277326 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141420 |
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130381 |
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130385 |
| AKT1 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-252568 |
| AKT1 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-252569 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-252484 |
| AKT | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251477 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-252486 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-252515 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168766 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168762 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-233529 |
| AKT | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251478 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-175291 |
| CDK2 | phosphorylation down-regulates | FOXO4 | SIGNOR-183655 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168758 |
| RALA | phosphorylation → up-regulates activity | FOXO4 | SIGNOR-249665 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-174021 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | FOXO4 | SIGNOR-277325 |
| PRKAA1 | phosphorylation → up-regulates | FOXO4 | SIGNOR-157947 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141424 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141416 |
