| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-141416 |
| AKT1 | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-252568 |
| AKT1 | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates | 16272144 | SIGNOR-252484 |
| AKT | FOXO4 | Ser197 | APRRRAAsMDSSSKL | phosphorylation down-regulates activity | 10217147 | SIGNOR-251477 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141416 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-252568 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-252484 |
| AKT | phosphorylation up-regulates → | FOXO4 PSer197 | phosphorylation down-regulates ⊣ | FOXO4 | 10217147 | SIGNOR-251477 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation![]() down-regulates | FOXO4 | SIGNOR-141416 |
| AKT1 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-252568 |
| AKT1 | phosphorylation![]() down-regulates | FOXO4 | SIGNOR-252484 |
| AKT | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251477 |