| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 11313479 | SIGNOR-251491 |
| AKT | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-141424 |
| AKT1 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-252486 |
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 16272144 | SIGNOR-248055 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 11313479 | SIGNOR-251491 |
| AKT | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-141424 |
| AKT1 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-252486 |
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-248055 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251491 |
| AKT | phosphorylation down-regulates | FOXO4 | SIGNOR-141424 |
| AKT1 | phosphorylation down-regulates | FOXO4 | SIGNOR-252486 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-248055 |
