| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RALA | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates activity | 11689711 | SIGNOR-248003 |
| MAPK8 | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 15538382 | SIGNOR-130381 |
| JNK | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 20959475 | SIGNOR-168762 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RALA | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 11689711 | SIGNOR-248003 |
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130381 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168762 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RALA | phosphorylation → up-regulates activity | FOXO4 | SIGNOR-248003 |
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130381 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168762 |
