| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 15538382 | SIGNOR-130385 |
| RALA | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates activity | 11689711 | SIGNOR-249665 |
| JNK | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 20959475 | SIGNOR-168766 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130385 |
| RALA | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 11689711 | SIGNOR-249665 |
| JNK | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 20959475 | SIGNOR-168766 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130385 |
| RALA | phosphorylation → up-regulates activity | FOXO4 | SIGNOR-249665 |
| JNK | phosphorylation → up-regulates | FOXO4 | SIGNOR-168766 |
