| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | CYCS | Tyr47 | KTGQAPGySYTAANK | phosphorylation down-regulates activity | 32781572 | SIGNOR-277236 |
| AKT1 | CYCS | Tyr47 | KTGQAPGySYTAANK | phosphorylation down-regulates activity | 32781572 | SIGNOR-277237 |
| AKT3 | CYCS | Tyr47 | KTGQAPGySYTAANK | phosphorylation down-regulates activity | 32781572 | SIGNOR-277235 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | CYCS PTyr47 | phosphorylation down-regulates ⊣ | CYCS | 32781572 | SIGNOR-277236 |
| AKT1 | phosphorylation up-regulates → | CYCS PTyr47 | phosphorylation down-regulates ⊣ | CYCS | 32781572 | SIGNOR-277237 |
| AKT3 | phosphorylation up-regulates → | CYCS PTyr47 | phosphorylation down-regulates ⊣ | CYCS | 32781572 | SIGNOR-277235 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation → down-regulates activity | CYCS | SIGNOR-277236 |
| AKT1 | phosphorylation → down-regulates activity | CYCS | SIGNOR-277237 |
| AKT3 | phosphorylation → down-regulates activity | CYCS | SIGNOR-277235 |