Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK3	ESR1	Ser104	FPPLNSVsPSPLMLL	phosphorylation up-regulates activity	26202215	SIGNOR-273189
CDK3	ESR1	Ser106	PLNSVSPsPLMLLHP	phosphorylation up-regulates activity	26202215	SIGNOR-273188
CDK3	ESR1	Ser118	LHPPPQLsPFLQPHG	phosphorylation up-regulates activity	26202215	SIGNOR-273187
CDK3	JUN	Ser63	KNSDLLTsPDVGLLK	phosphorylation up-regulates	19118012	SIGNOR-183009
CDK3	JUN	Ser73	VGLLKLAsPELERLI	phosphorylation up-regulates	19118012	SIGNOR-183013
CDK3	RB1	Ser811	IYISPLKsPYKISEG	phosphorylation down-regulates	15084261	SIGNOR-124212
CDK3	ATF1	Ser63	GILARRPsYRKILKD	phosphorylation up-regulates	18794154	SIGNOR-180920
CDK3	NOTCH1	Ser2513	EHPFLTPsPESPDQW	phosphorylation down-regulates quantity by destabilization	25344755	SIGNOR-273169
CDK3	NOTCH1	Ser2516	FLTPSPEsPDQWSSS	phosphorylation down-regulates quantity by destabilization	25344755	SIGNOR-273168
CDK3	NOTCH1	Thr2511	VPEHPFLtPSPESPD	phosphorylation down-regulates quantity by destabilization	25344755	SIGNOR-273167
CDK3	MECOM	Ser624	KMFKDKVsPLQNLAS	phosphorylation up-regulates activity	33082307	SIGNOR-273431
CDK3	TFCP2	Ser309	SLGEGNGsPNHQPEP	phosphorylation down-regulates	19237534	SIGNOR-184164
CDK3	NFATC4	Ser259	APGPTPAsPRPASPC	phosphorylation up-regulates activity	27893713	SIGNOR-278511
CDK3	LIN9	Thr96	KFTATMStPDKKASQ	phosphorylation up-regulates	24475316	SIGNOR-204529
CDK3	CABLES1	Ser273	PGQGGSTsAFEQLQR	phosphorylation unknown	11733001	SIGNOR-250679

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK3	phosphorylation up-regulates →	ESR1 PSer104	phosphorylation up-regulates →	ESR1	26202215	SIGNOR-273189
CDK3	phosphorylation up-regulates →	ESR1 PSer106	phosphorylation up-regulates →	ESR1	26202215	SIGNOR-273188
CDK3	phosphorylation up-regulates →	ESR1 PSer118	phosphorylation up-regulates →	ESR1	26202215	SIGNOR-273187
CDK3	phosphorylation up-regulates →	JUN PSer63	phosphorylation up-regulates →	JUN	19118012	SIGNOR-183009
CDK3	phosphorylation up-regulates →	JUN PSer73	phosphorylation up-regulates →	JUN	19118012	SIGNOR-183013
CDK3	phosphorylation up-regulates →	RB1 PSer811	phosphorylation down-regulates ⊣	RB1	15084261	SIGNOR-124212
CDK3	phosphorylation up-regulates →	ATF1 PSer63	phosphorylation up-regulates →	ATF1	18794154	SIGNOR-180920
CDK3	phosphorylation up-regulates →	NOTCH1 PSer2513	phosphorylation down-regulates ⊣	NOTCH1	25344755	SIGNOR-273169
CDK3	phosphorylation up-regulates →	NOTCH1 PSer2516	phosphorylation down-regulates ⊣	NOTCH1	25344755	SIGNOR-273168
CDK3	phosphorylation up-regulates →	NOTCH1 PThr2511	phosphorylation down-regulates ⊣	NOTCH1	25344755	SIGNOR-273167
CDK3	phosphorylation up-regulates →	MECOM PSer624	phosphorylation up-regulates →	MECOM	33082307	SIGNOR-273431
CDK3	phosphorylation up-regulates →	TFCP2 PSer309	phosphorylation down-regulates ⊣	TFCP2	19237534	SIGNOR-184164
CDK3	phosphorylation up-regulates →	NFATC4 PSer259	phosphorylation up-regulates →	NFATC4	27893713	SIGNOR-278511
CDK3	phosphorylation up-regulates →	LIN9 PThr96	phosphorylation up-regulates →	LIN9	24475316	SIGNOR-204529
CDK3	phosphorylation up-regulates →	CABLES1 PSer273	phosphorylation down-regulates ⊣	CABLES1	11733001	SIGNOR-250679

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK3	phosphorylation → up-regulates activity	ESR1	SIGNOR-273189
CDK3	phosphorylation → up-regulates activity	ESR1	SIGNOR-273188
CDK3	phosphorylation → up-regulates activity	ESR1	SIGNOR-273187
CDK3	phosphorylation → up-regulates	JUN	SIGNOR-183009
CDK3	phosphorylation → up-regulates	JUN	SIGNOR-183013
CDK3	phosphorylation down-regulates	RB1	SIGNOR-124212
CDK3	phosphorylation → up-regulates	ATF1	SIGNOR-180920
CDK3	phosphorylation down-regulates quantity by destabilization	NOTCH1	SIGNOR-273169
CDK3	phosphorylation down-regulates quantity by destabilization	NOTCH1	SIGNOR-273168
CDK3	phosphorylation down-regulates quantity by destabilization	NOTCH1	SIGNOR-273167
CDK3	phosphorylation → up-regulates activity	MECOM	SIGNOR-273431
CDK3	phosphorylation down-regulates	TFCP2	SIGNOR-184164
CDK3	phosphorylation → up-regulates activity	NFATC4	SIGNOR-278511
CDK3	phosphorylation → up-regulates	LIN9	SIGNOR-204529
CDK3	phosphorylation → unknown	CABLES1	SIGNOR-250679