| Name | CDK6 |
| ID | Q00534 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 13-300 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK6 | FOXO3 | Ser325 | STVSGRLsPIMASTE | phosphorylation up-regulates activity | 28778953 | SIGNOR-279023 |
| CDK6 | JUN | – | phosphorylation up-regulates quantity | 17454300 | SIGNOR-280222 | |
| CDK6 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135189 |
| CDK6 | PKM | – | phosphorylation down-regulates activity | 28607489 | SIGNOR-279158 | |
| CDK6 | TFEB | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279454 | |
| CDK6 | TFE3 | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279517 | |
| CDK6 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation down-regulates activity | 16508017 | SIGNOR-144832 |
| CDK6 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates | 16160006 | SIGNOR-140405 |
| CDK6 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 16160006 | SIGNOR-140401 |
| CDK6 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-138953 |
| CDK6 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates | 16046550 | SIGNOR-138957 |
| CDK6 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates | 16046550 | SIGNOR-138965 |
| CDK6 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates | 21059642 | SIGNOR-169326 |
| CDK6 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates | 21059642 | SIGNOR-169330 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138961 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-169334 |
| CDK6 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87113 |
| CDK6 | RBL2 | Ser1035 | NMDAPPLsPYPFVRT | phosphorylation unknown | 11157749 | SIGNOR-104711 |
| CDK6 | RBL2 | Ser672 | TLYDRYSsPPASTTR | phosphorylation unknown | 11157749 | SIGNOR-104715 |
| CDK6 | RBL2 | Thr401 | SKALRIStPLTGVRY | phosphorylation unknown | 11157749 | SIGNOR-104719 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK6 | phosphorylation up-regulates → | FOXO3 PSer325 | phosphorylation up-regulates → | FOXO3 | 28778953 | SIGNOR-279023 |
| CDK6 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135189 |
| CDK6 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation down-regulates ⊣ | CDKN1A | 16508017 | SIGNOR-144832 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 16160006 | SIGNOR-140405 |
| CDK6 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 16160006 | SIGNOR-140401 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138953 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138957 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138965 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169326 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169330 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138961 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169334 |
| CDK6 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87113 |
| CDK6 | phosphorylation up-regulates → | RBL2 PSer1035 | phosphorylation down-regulates ⊣ | RBL2 | 11157749 | SIGNOR-104711 |
| CDK6 | phosphorylation up-regulates → | RBL2 PSer672 | phosphorylation down-regulates ⊣ | RBL2 | 11157749 | SIGNOR-104715 |
| CDK6 | phosphorylation up-regulates → | RBL2 PThr401 | phosphorylation down-regulates ⊣ | RBL2 | 11157749 | SIGNOR-104719 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK6 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-279023 |
| CDK6 | phosphorylation → up-regulates quantity | JUN | SIGNOR-280222 |
| CDK6 | phosphorylation down-regulates | RB1 | SIGNOR-135189 |
| CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-279158 |
| CDK6 | phosphorylation → up-regulates activity | TFEB | SIGNOR-279454 |
| CDK6 | phosphorylation → up-regulates activity | TFE3 | SIGNOR-279517 |
| CDK6 | phosphorylation → down-regulates activity | CDKN1A | SIGNOR-144832 |
| CDK6 | phosphorylation down-regulates | CDKN1B | SIGNOR-140405 |
| CDK6 | phosphorylation → up-regulates | CDKN1B | SIGNOR-140401 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138953 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138957 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138965 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169326 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169330 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138961 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-169334 |
| CDK6 | phosphorylation down-regulates | PRDX1 | SIGNOR-87113 |
| CDK6 | phosphorylation → unknown | RBL2 | SIGNOR-104711 |
| CDK6 | phosphorylation → unknown | RBL2 | SIGNOR-104715 |
| CDK6 | phosphorylation → unknown | RBL2 | SIGNOR-104719 |