| Name | CDK5 |
| ID | Q00535 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 4-286 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | MAPK10 | Thr131 | ISLLNVFtPQKTLEE | phosphorylation down-regulates activity | 11823425 | SIGNOR-250668 |
| CDK5 | AMFR | Ser516 | SIRPALNsPVERPSS | phosphorylation down-regulates quantity by destabilization | 28528366 | SIGNOR-277356 |
| CDK5 | STMN3 | Ser73 | PESPMLSsPPKKKDT | phosphorylation unknown | 22577147 | SIGNOR-264894 |
| CDK5 | CLIC4 | Ser108 | PPKYLKLsPKHPESN | phosphorylation up-regulates quantity by stabilization | 30237421 | SIGNOR-279451 |
| CDK5 | TH | – | phosphorylation up-regulates activity | 15471880 | SIGNOR-279022 | |
| CDK5 | TPPP | Ser160 | GVTKAISsPTVSRLT | phosphorylation down-regulates activity | 17693641 | SIGNOR-262931 |
| CDK5 | EPRS1 | Ser886 | LSQSSDSsPTRNSEP | phosphorylation down-regulates | 21220307 | SIGNOR-171138 |
| CDK5 | CLOCK | Thr461 | KIPTDTStPPRQHLP | phosphorylation up-regulates | 24235147 | SIGNOR-203231 |
| CDK5 | CASK | – | phosphorylation up-regulates activity | 18054859 | SIGNOR-280216 | |
| CDK5 | MIB1 | – | phosphorylation up-regulates activity | 21763614 | SIGNOR-280217 | |
| CDK5 | PRKAA2 | – | phosphorylation down-regulates activity | 31786229 | SIGNOR-280218 | |
| CDK5 | SPAAR | – | phosphorylation down-regulates quantity by destabilization | 28502042 | SIGNOR-280219 | |
| CDK5 | TRIO | – | phosphorylation up-regulates activity | 15331630 | SIGNOR-280220 | |
| CDK5 | XDH | – | phosphorylation up-regulates activity | 25831123 | SIGNOR-280221 | |
| CDK5 | PARP1 | Ser786 | RGGSDDSsKDPIDVN | phosphorylation down-regulates activity | 21922195 | SIGNOR-276359 |
| CDK5 | BACE1 | Thr252 | YTGSLWYtPIRREWY | phosphorylation up-regulates activity | 26317805 | SIGNOR-278249 |
| CDK5 | DBN1 | Ser142 | NGLARLSsPVLHRLR | phosphorylation up-regulates activity | 23979715 | SIGNOR-279452 |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-249325 |
| CDK5 | CRMP1 | Thr509 | PVYEVPAtPKYATPA | phosphorylation up-regulates | 18003833 | SIGNOR-159318 |
| CDK5 | DLG4 | Ser25 | DTPPLEHsPAHLPNQ | phosphorylation down-regulates activity | 28502042 | SIGNOR-279150 |
| CDK5 | PEBP1 | Thr42 | DELGKVLtPTQVKNR | phosphorylation down-regulates quantity by destabilization | 25104559 | SIGNOR-276672 |
| CDK5 | MAPT | Ser552 | VVRTPPKsPSSAKSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249319 |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249322 |
| CDK5 | NOTCH1 | – | phosphorylation up-regulates activity | 33960694 | SIGNOR-279401 | |
| CDK5 | NR1I2 | – | phosphorylation down-regulates activity | 20553580 | SIGNOR-279402 | |
| CDK5 | CREB1 | – | phosphorylation up-regulates activity | 29742423 | SIGNOR-279682 | |
| CDK5 | NEFM | – | phosphorylation down-regulates quantity | 28634551 | SIGNOR-279683 | |
| CDK5 | NDEL1 | Ser231 | GTENTFPsPKAIPNG | phosphorylation up-regulates activity | 12796778 | SIGNOR-250676 |
| CDK5 | RAPGEF2 | Ser1124 | PPTSPQSsPRKGYTL | phosphorylation up-regulates activity | 25189171 | SIGNOR-278258 |
| CDK5 | ERBB3 | Thr873 | LLYSEAKtPIKWMAL | phosphorylation up-regulates activity | 12824184 | SIGNOR-250664 |
| CDK5 | HTT | Ser1199 | EQASVPLsPKKGSEA | phosphorylation up-regulates | 17611284 | SIGNOR-156840 |
| CDK5 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 17202132 | SIGNOR-151803 |
| CDK5 | DLC1 | – | phosphorylation up-regulates activity | 25452387 | SIGNOR-279602 | |
| CDK5 | SOX6 | – | phosphorylation down-regulates quantity | 24662752 | SIGNOR-279365 | |
| CDK5 | CABLES1 | Ser313 | RCRTLSGsPRPKNFK | phosphorylation unknown | 11733001 | SIGNOR-112418 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249317 |
| CDK5 | PMAIP1 | Ser13 | ARKNAQPsPARAPAE | phosphorylation down-regulates | 21145489 | SIGNOR-170357 |
| CDK5 | CDK5R1 | Thr138 | PAVTSAGtPKRVIVQ | phosphorylation down-regulates | 18326489 | SIGNOR-177967 |
| CDK5 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249327 |
| CDK5 | ERBB4 | Thr1152 | LDEEGYMtPMRDKPK | phosphorylation up-regulates activity | 24142862 | SIGNOR-278436 |
| CDK5 | VIM | Ser56 | SRSLYASsPGGVYAT | phosphorylation up-regulates activity | 21465480 | SIGNOR-278922 |
| CDK5 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation down-regulates activity | 26146988 | SIGNOR-279681 |
| CDK5 | CDKN1B | Thr187 | NAGSVEQtPKKPGLR | phosphorylation down-regulates activity | 26146988 | SIGNOR-279680 |
| CDK5 | HIF1A | Ser687 | TEKSHPRsPNVLSVA | phosphorylation up-regulates activity | 27027353 | SIGNOR-279020 |
| CDK5 | GRIN2A | Ser1232 | SGHFTMRsPFKCDAC | phosphorylation up-regulates activity | 11675505 | SIGNOR-250666 |
| CDK5 | NDEL1 | Ser198 | TRKSAPSsPTLDCEK | phosphorylation up-regulates activity | 12796778 | SIGNOR-250675 |
| CDK5 | DLG4 | Ser35 | HLPNQANsPPVIVNT | phosphorylation down-regulates activity | 28502042 | SIGNOR-279151 |
| CDK5 | DLG4 | Thr19 | YRYQDEDtPPLEHSP | phosphorylation down-regulates activity | 28502042 | SIGNOR-279152 |
| CDK5 | ERBB2 | – | phosphorylation up-regulates activity | 26509276 | SIGNOR-279155 | |
| CDK5 | SYNGAP1 | – | phosphorylation up-regulates activity | 26912996 | SIGNOR-279157 | |
| CDK5 | CTNND2 | – | phosphorylation up-regulates activity | 20573893 | SIGNOR-279323 | |
| CDK5 | TRPV1 | – | phosphorylation up-regulates activity | 26894912 | SIGNOR-278437 | |
| CDK5 | PPP1R9B | Ser17 | GGPLRSAsPHRSAYE | phosphorylation down-regulates quantity | 29786422 | SIGNOR-279453 |
| CDK5 | CTNNB1 | Ser246 | ALVKMLGsPVDSVLF | phosphorylation up-regulates activity | 26509276 | SIGNOR-279516 |
| CDK5 | MAPT | Ser713 | GAEIVYKsPVVSGDT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249320 |
| CDK5 | CALD1 | Ser789 | QSVDKVTsPTKV | phosphorylation down-regulates quantity by destabilization | 21791703 | SIGNOR-280215 |
| CDK5 | DNM1 | Ser778 | GRRSPTSsPTPQRRA | phosphorylation up-regulates activity | 12855954 | SIGNOR-250662 |
| CDK5 | HTR6 | Ser350 | ERQASLAsPSLRTSH | phosphorylation down-regulates activity | 32047117 | SIGNOR-264407 |
| CDK5 | DPYSL3 | Ser518 | KGGTPAGsARGSPTR | phosphorylation up-regulates activity | 16611631 | SIGNOR-145963 |
| CDK5 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15741232 | SIGNOR-134468 |
| CDK5 | CDK16 | – | phosphorylation up-regulates activity | 12084709 | SIGNOR-279149 | |
| CDK5 | PIP5K1C | Ser650 | DERSWVYsPLHYSAQ | phosphorylation down-regulates | 15738269 | SIGNOR-134455 |
| CDK5 | PPP1R2 | Thr73 | MKIDEPStPYHSMMG | phosphorylation unknown | 11320080 | SIGNOR-250672 |
| CDK5 | ALDH1A1 | Ser274 | TLELGGKsPCIVLAD | phosphorylation up-regulates quantity | 29948941 | SIGNOR-279399 |
| CDK5 | ATM | Ser794 | LSNCTKKsPNKIASG | phosphorylation up-regulates | 19151707 | SIGNOR-183454 |
| CDK5 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 17591690 | SIGNOR-156422 |
| CDK5 | DLC1 | Ser946 | SVSPCPSsPKQIHLD | phosphorylation up-regulates activity | 25452387 | SIGNOR-276446 |
| CDK5 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17591690 | SIGNOR-156418 |
| CDK5 | MEF2A | Ser408 | SIKSEPIsPPRDRMT | phosphorylation down-regulates activity | 12691662 | SIGNOR-100574 |
| CDK5 | PPARG | Ser273 | TGKTTDKsPFVIYDM | phosphorylation down-regulates activity | 25827822 | SIGNOR-278189 |
| CDK5 | EPRS1 | Ser886 | LSQSSDSsPTRNSEP | phosphorylation down-regulates | 19647514 | SIGNOR-187383 |
| CDK5 | TPX2 | Ser486 | LPITVPKsPAFALKN | phosphorylation up-regulates quantity by stabilization | 31272499 | SIGNOR-265100 |
| CDK5 | VRK3 | Ser108 | RPPTPKSsPQKTRKS | phosphorylation up-regulates activity | 27346674 | SIGNOR-275544 |
| CDK5 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173685 |
| CDK5 | PLD2 | Ser134 | ARFAVAYsPARDAGN | phosphorylation down-regulates activity | 18625302 | SIGNOR-276168 |
| CDK5 | ERBB3 | Ser1123 | RSRSRSRsPRPRGDS | phosphorylation up-regulates activity | 12824184 | SIGNOR-250663 |
| CDK5 | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249318 |
| CDK5 | PRNP | – | phosphorylation up-regulates quantity | 19587281 | SIGNOR-278920 | |
| CDK5 | NGEF | – | phosphorylation up-regulates activity | 28769056 | SIGNOR-279021 | |
| CDK5 | AMPH | Ser272 | EEPSPLPsPTASPNH | phosphorylation unknown | 11113134 | SIGNOR-250648 |
| CDK5 | DYNLL1 | – | phosphorylation up-regulates activity | 25452387 | SIGNOR-279154 | |
| CDK5 | MAPK7 | Thr733 | LPPVFSGtPKGSGAG | phosphorylation up-regulates activity | 27735944 | SIGNOR-279364 |
| CDK5 | SYNJ1 | Ser1147 | S-->A | phosphorylation down-regulates activity | 14704270 | SIGNOR-279685 |
| CDK5 | HTR1A | Thr314 | LPSEAGPtPCAPASF | phosphorylation down-regulates quantity by destabilization | 30712943 | SIGNOR-264406 |
| CDK5 | STMN1 | Ser38 | SVPEFPLsPPKKKDL | phosphorylation down-regulates | 20630875 | SIGNOR-166682 |
| CDK5 | PIK3C3 | Thr668 | ENLDLKLtPYKVLAT | phosphorylation down-regulates activity | 20513426 | SIGNOR-259811 |
| CDK5 | NR3C1 | Ser203 | DLEFSSGsPGKETNE | phosphorylation down-regulates activity | 17440046 | SIGNOR-154401 |
| CDK5 | CAMKK2 | Ser133 | LPYSPVSsPQSSPRL | phosphorylation down-regulates | 22778263 | SIGNOR-198115 |
| CDK5 | DNM1 | Ser774 | SVPAGRRsPTSSPTP | phosphorylation up-regulates activity | 12855954 | SIGNOR-250661 |
| CDK5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15096606 | SIGNOR-124325 |
| CDK5 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-249321 |
| CDK5 | NES | Thr315 | AENSRLQtPGGGSKT | phosphorylation unknown | 12832492 | SIGNOR-250670 |
| CDK5 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25730670 | SIGNOR-278275 |
| CDK5 | TLN1 | Ser425 | TMLEDSVsPKKSTVL | phosphorylation up-regulates | 19363486 | SIGNOR-185210 |
| CDK5 | DPYSL3 | Thr509 | PVFDLTTtPKGGTPA | phosphorylation up-regulates activity | 16611631 | SIGNOR-145967 |
| CDK5 | HTT | Ser1179 | LTNPPSLsPIRRKGK | phosphorylation up-regulates | 17611284 | SIGNOR-156836 |
| CDK5 | GRIN2B | Ser1116 | YRRRPPRsPDHKRYF | phosphorylation down-regulates quantity | 24607229 | SIGNOR-278265 |
| CDK5 | TPPP | Ser18 | ANRTPPKsPGDPSKD | phosphorylation down-regulates activity | 17693641 | SIGNOR-262932 |
| CDK5 | PTK2 | Ser732 | SSEGFYPsPQHMVQT | phosphorylation up-regulates | 12941275 | SIGNOR-86223 |
| CDK5 | PARP1 | Ser785 | LRGGSDDsSKDPIDV | phosphorylation down-regulates activity | 21922195 | SIGNOR-276358 |
| CDK5 | CRMP1 | Ser522 | PAPSAKSsPSKHQPP | phosphorylation up-regulates | 18003833 | SIGNOR-159314 |
| CDK5 | PRKN | Ser131 | HTDSRKDsPPAGSPA | phosphorylation down-regulates | 17327227 | SIGNOR-153445 |
| CDK5 | KALRN | – | phosphorylation up-regulates activity | 18628310 | SIGNOR-279603 | |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-92607 |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171022 |
| CDK5 | DLC1 | Ser642 | DSFGSLPsPKELSSF | phosphorylation up-regulates activity | 25452387 | SIGNOR-276444 |
| CDK5 | KIF13B | Thr506 | SEGQVMLtPQKNTRT | phosphorylation down-regulates activity | 27512725 | SIGNOR-262737 |
| CDK5 | PSEN1 | Thr354 | HLGPHRStPESRAAV | phosphorylation up-regulates | 12056836 | SIGNOR-89145 |
| CDK5 | CRMP1 | Thr509 | PVYEVPAtPKYATPA | phosphorylation up-regulates | 16611631 | SIGNOR-145912 |
| CDK5 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249323 |
| CDK5 | ADD1 | Thr724 | KKKKKFRtPSFLKKS | phosphorylation up-regulates activity | 31548578 | SIGNOR-277487 |
| CDK5 | SYN1 | Ser553 | ARPPASPsPQRQAGP | phosphorylation up-regulates | 10880969 | SIGNOR-78887 |
| CDK5 | DLC1 | Ser859 | RRENSSDsPKELKRR | phosphorylation up-regulates activity | 25452387 | SIGNOR-276445 |
| CDK5 | STMN3 | Ser68 | PSDLSPEsPMLSSPP | phosphorylation unknown | 22577147 | SIGNOR-264893 |
| CDK5 | NDEL1 | Ser242 | IPNGFGTsPLTPSAR | phosphorylation up-regulates activity | 12796778 | SIGNOR-250677 |
| CDK5 | PHACTR3 | Ser318 | QGRESKGsPKKRLDV | phosphorylation down-regulates quantity | 21487013 | SIGNOR-273607 |
| CDK5 | PARP1 | Ser782 | YSLLRGGsDDSSKDP | phosphorylation down-regulates activity | 21922195 | SIGNOR-276357 |
| CDK5 | NES | Thr1299 | GETLPDStPLGFYLR | phosphorylation unknown | 12832492 | SIGNOR-250669 |
| CDK5 | LMTK2 | Ser1450 | LQTSKYFsPPPPARS | phosphorylation up-regulates | 22220831 | SIGNOR-195329 |
| CDK5 | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249326 |
| CDK5 | PLD2 | Ser134 | ARFAVAYsPARDAGN | phosphorylation up-regulates activity | 18625302 | SIGNOR-278395 |
| CDK5 | DLC1 | Ser557 | LEEFDVFsPKQDLVP | phosphorylation up-regulates activity | 25452387 | SIGNOR-276443 |
| CDK5 | CLOCK | Thr451 | AVSDPSStPTKIPTD | phosphorylation up-regulates | 24235147 | SIGNOR-203227 |
| CDK5 | MEF2D | Ser444 | SIKSEPVsPSRERSP | phosphorylation down-regulates activity | 19812325 | SIGNOR-279509 |
| CDK5 | TRIM59 | Ser308 | LIPKMKIsPKRMSCS | phosphorylation up-regulates activity | 31488827 | SIGNOR-272929 |
| CDK5 | FOXC2 | – | phosphorylation up-regulates activity | 26327394 | SIGNOR-279156 | |
| CDK5 | SYN1 | Ser551 | PAARPPAsPSPQRQA | phosphorylation up-regulates | 10880969 | SIGNOR-78883 |
| CDK5 | CAMKK2 | Ser137 | PVSSPQSsPRLPRRP | phosphorylation down-regulates | 22778263 | SIGNOR-197945 |
| CDK5 | AR | Ser83 | QQQQQETsPRQQQQQ | phosphorylation up-regulates | 21799006 | SIGNOR-175696 |
| CDK5 | CTNNB1 | Ser191 | SRHAIMRsPQMVSAI | phosphorylation up-regulates activity | 26509276 | SIGNOR-279515 |
| CDK5 | NOS3 | Ser114 | RKLQGRPsPGPPAPE | phosphorylation down-regulates | 20213743 | SIGNOR-164080 |
| CDK5 | BAG3 | Ser291 | STPLHSPsPIRVHTV | phosphorylation down-regulates quantity by destabilization | 31955914 | SIGNOR-277502 |
| CDK5 | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | phosphorylation unknown | 11278334 | SIGNOR-249194 |
| CDK5 | DPYSL2 | Ser522 | PASSAKTsPAKQQAP | phosphorylation down-regulates activity | 25040932 | SIGNOR-264838 |
| CDK5 | MAPT | Ser235 | SPQDSPPsKASPAQD | phosphorylation down-regulates | 21215781 | SIGNOR-171018 |
| CDK5 | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates activity | 12387894 | SIGNOR-249324 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-92603 |
| CDK5 | PIK3C3 | Thr159 | DGSEPTKtPGRTSST | phosphorylation down-regulates | 20513426 | SIGNOR-165772 |
| CDK5 | TPPP | Thr14 | PAKAANRtPPKSPGD | phosphorylation down-regulates activity | 17693641 | SIGNOR-262933 |
| CDK5 | CDH1 | – | phosphorylation down-regulates activity | 22836916 | SIGNOR-279679 | |
| CDK5 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation up-regulates activity | 35443760 | SIGNOR-279684 |
| CDK5 | PP1 | – | phosphorylation down-regulates activity | 12202491 | SIGNOR-264649 | |
| CDK5 | DLGAP1 | Ser77 | FPRRHYTsQQELKDE | phosphorylation down-regulates quantity by destabilization | 21829588 | SIGNOR-279153 |
| CDK5 | DPYSL3 | Thr514 | TTTPKGGtPAGSARG | phosphorylation up-regulates activity | 16611631 | SIGNOR-145971 |
| CDK5 | NFAT5 | Thr135 | TVQQHPStPKRHTVL | phosphorylation up-regulates | 21209322 | SIGNOR-170886 |
| CDK5 | AMPH | Ser285 | NHTLAPAsPAPARPR | phosphorylation unknown | 11113134 | SIGNOR-250650 |
| CDK5 | CORO1A | Thr424 | AAPEASGtPSSDAVS | phosphorylation up-regulates activity | 26823173 | SIGNOR-245187 |
| CDK5 | LMTK2 | – | phosphorylation down-regulates | 12832520 | SIGNOR-102652 | |
| CDK5 | PPP1R1B | Thr75 | RPNPCAYtPPSLKAV | phosphorylation up-regulates activity | 10604473 | SIGNOR-250671 |
| CDK5 | HTRA2 | Ser400 | IHKVILGsPAHRAGL | phosphorylation up-regulates | 21701498 | SIGNOR-174598 |
| CDK5 | PAK1 | Thr212 | VIEPLPVtPTRDVAT | phosphorylation down-regulates activity | 11604394 | SIGNOR-249328 |
| CDK5 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17591690 | SIGNOR-156414 |
| CDK5 | STXBP2 | Thr572 | IGSSHILtPTRFLDD | phosphorylation down-regulates | 17716669 | SIGNOR-157528 |
| CDK5 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 12202491 | SIGNOR-92269 |
| CDK5 | CAMKK2 | Ser129 | ICPSLPYsPVSSPQS | phosphorylation down-regulates | 22778263 | SIGNOR-198111 |
| CDK5 | SRC | Ser75 | NSSDTVTsPQRAGPL | phosphorylation up-regulates | 10544291 | SIGNOR-71950 |
| CDK5 | CDK5R1 | Ser8 | MGTVLSLsPSYRKAT | phosphorylation down-regulates | 18326489 | SIGNOR-177963 |
| CDK5 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation unknown | 10936190 | SIGNOR-250651 |
| CDK5 | EZR | Thr235 | YEKDDKLtPKIGFPW | phosphorylation up-regulates activity | 12769842 | SIGNOR-250665 |
| CDK5 | AMPH | Ser276 | PLPSPTAsPNHTLAP | phosphorylation unknown | 11113134 | SIGNOR-250649 |
| CDK5 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17591690 | SIGNOR-156426 |
| CDK5 | PXN | Ser85 | HQQPQSSsPVYGSSA | phosphorylation up-regulates activity | 14970194 | SIGNOR-278921 |
| CDK5 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation down-regulates activity | 17440046 | SIGNOR-154405 |
| CDK5 | LMTK2 | – | phosphorylation down-regulates | 12832520 | SIGNOR-102717 | |
| CDK5 | AGAP2 | Ser279 | KSKTLDNsDLHPGPP | phosphorylation up-regulates | 18487454 | SIGNOR-178660 |
| CDK5 | APEX1 | Thr233 | NKKNAGFtPQERQGF | phosphorylation up-regulates activity | 21727086 | SIGNOR-276337 |
| CDK5 | DRD2 | Ser321 | GLHSTPDsPAKPEKN | phosphorylation down-regulates activity | 24391960 | SIGNOR-259401 |
| CDK5 | ALDH1A1 | Ser75 | RQAFQIGsPWRTMDA | phosphorylation up-regulates quantity | 29948941 | SIGNOR-279400 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | MAPK10 PThr131 | phosphorylation down-regulates ⊣ | MAPK10 | 11823425 | SIGNOR-250668 |
| CDK5 | phosphorylation up-regulates → | AMFR PSer516 | phosphorylation down-regulates ⊣ | AMFR | 28528366 | SIGNOR-277356 |
| CDK5 | phosphorylation up-regulates → | STMN3 PSer73 | phosphorylation down-regulates ⊣ | STMN3 | 22577147 | SIGNOR-264894 |
| CDK5 | phosphorylation up-regulates → | CLIC4 PSer108 | phosphorylation up-regulates → | CLIC4 | 30237421 | SIGNOR-279451 |
| CDK5 | phosphorylation up-regulates → | TPPP PSer160 | phosphorylation down-regulates ⊣ | TPPP | 17693641 | SIGNOR-262931 |
| CDK5 | phosphorylation up-regulates → | EPRS1 PSer886 | phosphorylation down-regulates ⊣ | EPRS1 | 21220307 | SIGNOR-171138 |
| CDK5 | phosphorylation up-regulates → | CLOCK PThr461 | phosphorylation up-regulates → | CLOCK | 24235147 | SIGNOR-203231 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer786 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276359 |
| CDK5 | phosphorylation up-regulates → | BACE1 PThr252 | phosphorylation up-regulates → | BACE1 | 26317805 | SIGNOR-278249 |
| CDK5 | phosphorylation up-regulates → | DBN1 PSer142 | phosphorylation up-regulates → | DBN1 | 23979715 | SIGNOR-279452 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249325 |
| CDK5 | phosphorylation up-regulates → | CRMP1 PThr509 | phosphorylation up-regulates → | CRMP1 | 18003833 | SIGNOR-159318 |
| CDK5 | phosphorylation up-regulates → | DLG4 PSer25 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279150 |
| CDK5 | phosphorylation up-regulates → | PEBP1 PThr42 | phosphorylation down-regulates ⊣ | PEBP1 | 25104559 | SIGNOR-276672 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer552 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249319 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249322 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer231 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250676 |
| CDK5 | phosphorylation up-regulates → | RAPGEF2 PSer1124 | phosphorylation up-regulates → | RAPGEF2 | 25189171 | SIGNOR-278258 |
| CDK5 | phosphorylation up-regulates → | ERBB3 PThr873 | phosphorylation up-regulates → | ERBB3 | 12824184 | SIGNOR-250664 |
| CDK5 | phosphorylation up-regulates → | HTT PSer1199 | phosphorylation up-regulates → | HTT | 17611284 | SIGNOR-156840 |
| CDK5 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 17202132 | SIGNOR-151803 |
| CDK5 | phosphorylation up-regulates → | CABLES1 PSer313 | phosphorylation down-regulates ⊣ | CABLES1 | 11733001 | SIGNOR-112418 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249317 |
| CDK5 | phosphorylation up-regulates → | PMAIP1 PSer13 | phosphorylation down-regulates ⊣ | PMAIP1 | 21145489 | SIGNOR-170357 |
| CDK5 | phosphorylation up-regulates → | CDK5R1 PThr138 | phosphorylation down-regulates ⊣ | CDK5R1 | 18326489 | SIGNOR-177967 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249327 |
| CDK5 | phosphorylation up-regulates → | ERBB4 PThr1152 | phosphorylation up-regulates → | ERBB4 | 24142862 | SIGNOR-278436 |
| CDK5 | phosphorylation up-regulates → | VIM PSer56 | phosphorylation up-regulates → | VIM | 21465480 | SIGNOR-278922 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279681 |
| CDK5 | phosphorylation up-regulates → | CDKN1B PThr187 | phosphorylation down-regulates ⊣ | CDKN1B | 26146988 | SIGNOR-279680 |
| CDK5 | phosphorylation up-regulates → | HIF1A PSer687 | phosphorylation up-regulates → | HIF1A | 27027353 | SIGNOR-279020 |
| CDK5 | phosphorylation up-regulates → | GRIN2A PSer1232 | phosphorylation up-regulates → | GRIN2A | 11675505 | SIGNOR-250666 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer198 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250675 |
| CDK5 | phosphorylation up-regulates → | DLG4 PSer35 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279151 |
| CDK5 | phosphorylation up-regulates → | DLG4 PThr19 | phosphorylation down-regulates ⊣ | DLG4 | 28502042 | SIGNOR-279152 |
| CDK5 | phosphorylation up-regulates → | PPP1R9B PSer17 | phosphorylation down-regulates ⊣ | PPP1R9B | 29786422 | SIGNOR-279453 |
| CDK5 | phosphorylation up-regulates → | CTNNB1 PSer246 | phosphorylation up-regulates → | CTNNB1 | 26509276 | SIGNOR-279516 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer713 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249320 |
| CDK5 | phosphorylation up-regulates → | CALD1 PSer789 | phosphorylation down-regulates ⊣ | CALD1 | 21791703 | SIGNOR-280215 |
| CDK5 | phosphorylation up-regulates → | DNM1 PSer778 | phosphorylation up-regulates → | DNM1 | 12855954 | SIGNOR-250662 |
| CDK5 | phosphorylation up-regulates → | HTR6 PSer350 | phosphorylation down-regulates ⊣ | HTR6 | 32047117 | SIGNOR-264407 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PSer518 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145963 |
| CDK5 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15741232 | SIGNOR-134468 |
| CDK5 | phosphorylation up-regulates → | PIP5K1C PSer650 | phosphorylation down-regulates ⊣ | PIP5K1C | 15738269 | SIGNOR-134455 |
| CDK5 | phosphorylation up-regulates → | PPP1R2 PThr73 | phosphorylation down-regulates ⊣ | PPP1R2 | 11320080 | SIGNOR-250672 |
| CDK5 | phosphorylation up-regulates → | ALDH1A1 PSer274 | phosphorylation up-regulates → | ALDH1A1 | 29948941 | SIGNOR-279399 |
| CDK5 | phosphorylation up-regulates → | ATM PSer794 | phosphorylation up-regulates → | ATM | 19151707 | SIGNOR-183454 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156422 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer946 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276446 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156418 |
| CDK5 | phosphorylation up-regulates → | MEF2A PSer408 | phosphorylation down-regulates ⊣ | MEF2A | 12691662 | SIGNOR-100574 |
| CDK5 | phosphorylation up-regulates → | PPARG PSer273 | phosphorylation down-regulates ⊣ | PPARG | 25827822 | SIGNOR-278189 |
| CDK5 | phosphorylation up-regulates → | EPRS1 PSer886 | phosphorylation down-regulates ⊣ | EPRS1 | 19647514 | SIGNOR-187383 |
| CDK5 | phosphorylation up-regulates → | TPX2 PSer486 | phosphorylation up-regulates → | TPX2 | 31272499 | SIGNOR-265100 |
| CDK5 | phosphorylation up-regulates → | VRK3 PSer108 | phosphorylation up-regulates → | VRK3 | 27346674 | SIGNOR-275544 |
| CDK5 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173685 |
| CDK5 | phosphorylation up-regulates → | PLD2 PSer134 | phosphorylation down-regulates ⊣ | PLD2 | 18625302 | SIGNOR-276168 |
| CDK5 | phosphorylation up-regulates → | ERBB3 PSer1123 | phosphorylation up-regulates → | ERBB3 | 12824184 | SIGNOR-250663 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249318 |
| CDK5 | phosphorylation up-regulates → | AMPH PSer272 | phosphorylation down-regulates ⊣ | AMPH | 11113134 | SIGNOR-250648 |
| CDK5 | phosphorylation up-regulates → | MAPK7 PThr733 | phosphorylation up-regulates → | MAPK7 | 27735944 | SIGNOR-279364 |
| CDK5 | phosphorylation up-regulates → | SYNJ1 PSer1147 | phosphorylation down-regulates ⊣ | SYNJ1 | 14704270 | SIGNOR-279685 |
| CDK5 | phosphorylation up-regulates → | HTR1A PThr314 | phosphorylation down-regulates ⊣ | HTR1A | 30712943 | SIGNOR-264406 |
| CDK5 | phosphorylation up-regulates → | STMN1 PSer38 | phosphorylation down-regulates ⊣ | STMN1 | 20630875 | SIGNOR-166682 |
| CDK5 | phosphorylation up-regulates → | PIK3C3 PThr668 | phosphorylation down-regulates ⊣ | PIK3C3 | 20513426 | SIGNOR-259811 |
| CDK5 | phosphorylation up-regulates → | NR3C1 PSer203 | phosphorylation down-regulates ⊣ | NR3C1 | 17440046 | SIGNOR-154401 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer133 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198115 |
| CDK5 | phosphorylation up-regulates → | DNM1 PSer774 | phosphorylation up-regulates → | DNM1 | 12855954 | SIGNOR-250661 |
| CDK5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15096606 | SIGNOR-124325 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249321 |
| CDK5 | phosphorylation up-regulates → | NES PThr315 | phosphorylation down-regulates ⊣ | NES | 12832492 | SIGNOR-250670 |
| CDK5 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25730670 | SIGNOR-278275 |
| CDK5 | phosphorylation up-regulates → | TLN1 PSer425 | phosphorylation up-regulates → | TLN1 | 19363486 | SIGNOR-185210 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PThr509 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145967 |
| CDK5 | phosphorylation up-regulates → | HTT PSer1179 | phosphorylation up-regulates → | HTT | 17611284 | SIGNOR-156836 |
| CDK5 | phosphorylation up-regulates → | GRIN2B PSer1116 | phosphorylation down-regulates ⊣ | GRIN2B | 24607229 | SIGNOR-278265 |
| CDK5 | phosphorylation up-regulates → | TPPP PSer18 | phosphorylation down-regulates ⊣ | TPPP | 17693641 | SIGNOR-262932 |
| CDK5 | phosphorylation up-regulates → | PTK2 PSer732 | phosphorylation up-regulates → | PTK2 | 12941275 | SIGNOR-86223 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer785 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276358 |
| CDK5 | phosphorylation up-regulates → | CRMP1 PSer522 | phosphorylation up-regulates → | CRMP1 | 18003833 | SIGNOR-159314 |
| CDK5 | phosphorylation up-regulates → | PRKN PSer131 | phosphorylation down-regulates ⊣ | PRKN | 17327227 | SIGNOR-153445 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92607 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171022 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer642 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276444 |
| CDK5 | phosphorylation up-regulates → | KIF13B PThr506 | phosphorylation down-regulates ⊣ | KIF13B | 27512725 | SIGNOR-262737 |
| CDK5 | phosphorylation up-regulates → | PSEN1 PThr354 | phosphorylation up-regulates → | PSEN1 | 12056836 | SIGNOR-89145 |
| CDK5 | phosphorylation up-regulates → | CRMP1 PThr509 | phosphorylation up-regulates → | CRMP1 | 16611631 | SIGNOR-145912 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249323 |
| CDK5 | phosphorylation up-regulates → | ADD1 PThr724 | phosphorylation up-regulates → | ADD1 | 31548578 | SIGNOR-277487 |
| CDK5 | phosphorylation up-regulates → | SYN1 PSer553 | phosphorylation up-regulates → | SYN1 | 10880969 | SIGNOR-78887 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer859 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276445 |
| CDK5 | phosphorylation up-regulates → | STMN3 PSer68 | phosphorylation down-regulates ⊣ | STMN3 | 22577147 | SIGNOR-264893 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer242 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250677 |
| CDK5 | phosphorylation up-regulates → | PHACTR3 PSer318 | phosphorylation down-regulates ⊣ | PHACTR3 | 21487013 | SIGNOR-273607 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer782 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276357 |
| CDK5 | phosphorylation up-regulates → | NES PThr1299 | phosphorylation down-regulates ⊣ | NES | 12832492 | SIGNOR-250669 |
| CDK5 | phosphorylation up-regulates → | LMTK2 PSer1450 | phosphorylation up-regulates → | LMTK2 | 22220831 | SIGNOR-195329 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249326 |
| CDK5 | phosphorylation up-regulates → | PLD2 PSer134 | phosphorylation up-regulates → | PLD2 | 18625302 | SIGNOR-278395 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer557 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276443 |
| CDK5 | phosphorylation up-regulates → | CLOCK PThr451 | phosphorylation up-regulates → | CLOCK | 24235147 | SIGNOR-203227 |
| CDK5 | phosphorylation up-regulates → | MEF2D PSer444 | phosphorylation down-regulates ⊣ | MEF2D | 19812325 | SIGNOR-279509 |
| CDK5 | phosphorylation up-regulates → | TRIM59 PSer308 | phosphorylation up-regulates → | TRIM59 | 31488827 | SIGNOR-272929 |
| CDK5 | phosphorylation up-regulates → | SYN1 PSer551 | phosphorylation up-regulates → | SYN1 | 10880969 | SIGNOR-78883 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer137 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-197945 |
| CDK5 | phosphorylation up-regulates → | AR PSer83 | phosphorylation up-regulates → | AR | 21799006 | SIGNOR-175696 |
| CDK5 | phosphorylation up-regulates → | CTNNB1 PSer191 | phosphorylation up-regulates → | CTNNB1 | 26509276 | SIGNOR-279515 |
| CDK5 | phosphorylation up-regulates → | NOS3 PSer114 | phosphorylation down-regulates ⊣ | NOS3 | 20213743 | SIGNOR-164080 |
| CDK5 | phosphorylation up-regulates → | BAG3 PSer291 | phosphorylation down-regulates ⊣ | BAG3 | 31955914 | SIGNOR-277502 |
| CDK5 | phosphorylation up-regulates → | PPP1R1A PSer67 | phosphorylation down-regulates ⊣ | PPP1R1A | 11278334 | SIGNOR-249194 |
| CDK5 | phosphorylation up-regulates → | DPYSL2 PSer522 | phosphorylation down-regulates ⊣ | DPYSL2 | 25040932 | SIGNOR-264838 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer235 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171018 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249324 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92603 |
| CDK5 | phosphorylation up-regulates → | PIK3C3 PThr159 | phosphorylation down-regulates ⊣ | PIK3C3 | 20513426 | SIGNOR-165772 |
| CDK5 | phosphorylation up-regulates → | TPPP PThr14 | phosphorylation down-regulates ⊣ | TPPP | 17693641 | SIGNOR-262933 |
| CDK5 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation up-regulates → | SIRT2 | 35443760 | SIGNOR-279684 |
| CDK5 | phosphorylation up-regulates → | DLGAP1 PSer77 | phosphorylation down-regulates ⊣ | DLGAP1 | 21829588 | SIGNOR-279153 |
| CDK5 | phosphorylation up-regulates → | DPYSL3 PThr514 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145971 |
| CDK5 | phosphorylation up-regulates → | NFAT5 PThr135 | phosphorylation up-regulates → | NFAT5 | 21209322 | SIGNOR-170886 |
| CDK5 | phosphorylation up-regulates → | AMPH PSer285 | phosphorylation down-regulates ⊣ | AMPH | 11113134 | SIGNOR-250650 |
| CDK5 | phosphorylation up-regulates → | CORO1A PThr424 | phosphorylation up-regulates → | CORO1A | 26823173 | SIGNOR-245187 |
| CDK5 | phosphorylation up-regulates → | PPP1R1B PThr75 | phosphorylation up-regulates → | PPP1R1B | 10604473 | SIGNOR-250671 |
| CDK5 | phosphorylation up-regulates → | HTRA2 PSer400 | phosphorylation up-regulates → | HTRA2 | 21701498 | SIGNOR-174598 |
| CDK5 | phosphorylation up-regulates → | PAK1 PThr212 | phosphorylation down-regulates ⊣ | PAK1 | 11604394 | SIGNOR-249328 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156414 |
| CDK5 | phosphorylation up-regulates → | STXBP2 PThr572 | phosphorylation down-regulates ⊣ | STXBP2 | 17716669 | SIGNOR-157528 |
| CDK5 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 12202491 | SIGNOR-92269 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer129 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198111 |
| CDK5 | phosphorylation up-regulates → | SRC PSer75 | phosphorylation up-regulates → | SRC | 10544291 | SIGNOR-71950 |
| CDK5 | phosphorylation up-regulates → | CDK5R1 PSer8 | phosphorylation down-regulates ⊣ | CDK5R1 | 18326489 | SIGNOR-177963 |
| CDK5 | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 10936190 | SIGNOR-250651 |
| CDK5 | phosphorylation up-regulates → | EZR PThr235 | phosphorylation up-regulates → | EZR | 12769842 | SIGNOR-250665 |
| CDK5 | phosphorylation up-regulates → | AMPH PSer276 | phosphorylation down-regulates ⊣ | AMPH | 11113134 | SIGNOR-250649 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156426 |
| CDK5 | phosphorylation up-regulates → | PXN PSer85 | phosphorylation up-regulates → | PXN | 14970194 | SIGNOR-278921 |
| CDK5 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation down-regulates ⊣ | NR3C1 | 17440046 | SIGNOR-154405 |
| CDK5 | phosphorylation up-regulates → | AGAP2 PSer279 | phosphorylation up-regulates → | AGAP2 | 18487454 | SIGNOR-178660 |
| CDK5 | phosphorylation up-regulates → | APEX1 PThr233 | phosphorylation up-regulates → | APEX1 | 21727086 | SIGNOR-276337 |
| CDK5 | phosphorylation up-regulates → | DRD2 PSer321 | phosphorylation down-regulates ⊣ | DRD2 | 24391960 | SIGNOR-259401 |
| CDK5 | phosphorylation up-regulates → | ALDH1A1 PSer75 | phosphorylation up-regulates → | ALDH1A1 | 29948941 | SIGNOR-279400 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5 | phosphorylation → down-regulates activity | MAPK10 | SIGNOR-250668 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | AMFR | SIGNOR-277356 |
| CDK5 | phosphorylation → unknown | STMN3 | SIGNOR-264894 |
| CDK5 | phosphorylation → up-regulates quantity by stabilization | CLIC4 | SIGNOR-279451 |
| CDK5 | phosphorylation → up-regulates activity | TH | SIGNOR-279022 |
| CDK5 | phosphorylation → down-regulates activity | TPPP | SIGNOR-262931 |
| CDK5 | phosphorylation down-regulates | EPRS1 | SIGNOR-171138 |
| CDK5 | phosphorylation → up-regulates | CLOCK | SIGNOR-203231 |
| CDK5 | phosphorylation → up-regulates activity | CASK | SIGNOR-280216 |
| CDK5 | phosphorylation → up-regulates activity | MIB1 | SIGNOR-280217 |
| CDK5 | phosphorylation → down-regulates activity | PRKAA2 | SIGNOR-280218 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | SPAAR | SIGNOR-280219 |
| CDK5 | phosphorylation → up-regulates activity | TRIO | SIGNOR-280220 |
| CDK5 | phosphorylation → up-regulates activity | XDH | SIGNOR-280221 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276359 |
| CDK5 | phosphorylation → up-regulates activity | BACE1 | SIGNOR-278249 |
| CDK5 | phosphorylation → up-regulates activity | DBN1 | SIGNOR-279452 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249325 |
| CDK5 | phosphorylation → up-regulates | CRMP1 | SIGNOR-159318 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279150 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | PEBP1 | SIGNOR-276672 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249319 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249322 |
| CDK5 | phosphorylation → up-regulates activity | NOTCH1 | SIGNOR-279401 |
| CDK5 | phosphorylation → down-regulates activity | NR1I2 | SIGNOR-279402 |
| CDK5 | phosphorylation → up-regulates activity | CREB1 | SIGNOR-279682 |
| CDK5 | phosphorylation → down-regulates quantity | NEFM | SIGNOR-279683 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250676 |
| CDK5 | phosphorylation → up-regulates activity | RAPGEF2 | SIGNOR-278258 |
| CDK5 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-250664 |
| CDK5 | phosphorylation → up-regulates | HTT | SIGNOR-156840 |
| CDK5 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-151803 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-279602 |
| CDK5 | phosphorylation → down-regulates quantity | SOX6 | SIGNOR-279365 |
| CDK5 | phosphorylation → unknown | CABLES1 | SIGNOR-112418 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249317 |
| CDK5 | phosphorylation down-regulates | PMAIP1 | SIGNOR-170357 |
| CDK5 | phosphorylation down-regulates | CDK5R1 | SIGNOR-177967 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249327 |
| CDK5 | phosphorylation → up-regulates activity | ERBB4 | SIGNOR-278436 |
| CDK5 | phosphorylation → up-regulates activity | VIM | SIGNOR-278922 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279681 |
| CDK5 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-279680 |
| CDK5 | phosphorylation → up-regulates activity | HIF1A | SIGNOR-279020 |
| CDK5 | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-250666 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250675 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279151 |
| CDK5 | phosphorylation → down-regulates activity | DLG4 | SIGNOR-279152 |
| CDK5 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-279155 |
| CDK5 | phosphorylation → up-regulates activity | SYNGAP1 | SIGNOR-279157 |
| CDK5 | phosphorylation → up-regulates activity | CTNND2 | SIGNOR-279323 |
| CDK5 | phosphorylation → up-regulates activity | TRPV1 | SIGNOR-278437 |
| CDK5 | phosphorylation → down-regulates quantity | PPP1R9B | SIGNOR-279453 |
| CDK5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279516 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249320 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | CALD1 | SIGNOR-280215 |
| CDK5 | phosphorylation → up-regulates activity | DNM1 | SIGNOR-250662 |
| CDK5 | phosphorylation → down-regulates activity | HTR6 | SIGNOR-264407 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145963 |
| CDK5 | phosphorylation down-regulates | RB1 | SIGNOR-134468 |
| CDK5 | phosphorylation → up-regulates activity | CDK16 | SIGNOR-279149 |
| CDK5 | phosphorylation down-regulates | PIP5K1C | SIGNOR-134455 |
| CDK5 | phosphorylation → unknown | PPP1R2 | SIGNOR-250672 |
| CDK5 | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-279399 |
| CDK5 | phosphorylation → up-regulates | ATM | SIGNOR-183454 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156422 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276446 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156418 |
| CDK5 | phosphorylation → down-regulates activity | MEF2A | SIGNOR-100574 |
| CDK5 | phosphorylation → down-regulates activity | PPARG | SIGNOR-278189 |
| CDK5 | phosphorylation down-regulates | EPRS1 | SIGNOR-187383 |
| CDK5 | phosphorylation → up-regulates quantity by stabilization | TPX2 | SIGNOR-265100 |
| CDK5 | phosphorylation → up-regulates activity | VRK3 | SIGNOR-275544 |
| CDK5 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173685 |
| CDK5 | phosphorylation → down-regulates activity | PLD2 | SIGNOR-276168 |
| CDK5 | phosphorylation → up-regulates activity | ERBB3 | SIGNOR-250663 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249318 |
| CDK5 | phosphorylation → up-regulates quantity | PRNP | SIGNOR-278920 |
| CDK5 | phosphorylation → up-regulates activity | NGEF | SIGNOR-279021 |
| CDK5 | phosphorylation → unknown | AMPH | SIGNOR-250648 |
| CDK5 | phosphorylation → up-regulates activity | DYNLL1 | SIGNOR-279154 |
| CDK5 | phosphorylation → up-regulates activity | MAPK7 | SIGNOR-279364 |
| CDK5 | phosphorylation → down-regulates activity | SYNJ1 | SIGNOR-279685 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | HTR1A | SIGNOR-264406 |
| CDK5 | phosphorylation down-regulates | STMN1 | SIGNOR-166682 |
| CDK5 | phosphorylation → down-regulates activity | PIK3C3 | SIGNOR-259811 |
| CDK5 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-154401 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-198115 |
| CDK5 | phosphorylation → up-regulates activity | DNM1 | SIGNOR-250661 |
| CDK5 | phosphorylation → up-regulates | STAT3 | SIGNOR-124325 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249321 |
| CDK5 | phosphorylation → unknown | NES | SIGNOR-250670 |
| CDK5 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278275 |
| CDK5 | phosphorylation → up-regulates | TLN1 | SIGNOR-185210 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145967 |
| CDK5 | phosphorylation → up-regulates | HTT | SIGNOR-156836 |
| CDK5 | phosphorylation → down-regulates quantity | GRIN2B | SIGNOR-278265 |
| CDK5 | phosphorylation → down-regulates activity | TPPP | SIGNOR-262932 |
| CDK5 | phosphorylation → up-regulates | PTK2 | SIGNOR-86223 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276358 |
| CDK5 | phosphorylation → up-regulates | CRMP1 | SIGNOR-159314 |
| CDK5 | phosphorylation down-regulates | PRKN | SIGNOR-153445 |
| CDK5 | phosphorylation → up-regulates activity | KALRN | SIGNOR-279603 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92607 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-171022 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276444 |
| CDK5 | phosphorylation → down-regulates activity | KIF13B | SIGNOR-262737 |
| CDK5 | phosphorylation → up-regulates | PSEN1 | SIGNOR-89145 |
| CDK5 | phosphorylation → up-regulates | CRMP1 | SIGNOR-145912 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249323 |
| CDK5 | phosphorylation → up-regulates activity | ADD1 | SIGNOR-277487 |
| CDK5 | phosphorylation → up-regulates | SYN1 | SIGNOR-78887 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276445 |
| CDK5 | phosphorylation → unknown | STMN3 | SIGNOR-264893 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250677 |
| CDK5 | phosphorylation → down-regulates quantity | PHACTR3 | SIGNOR-273607 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276357 |
| CDK5 | phosphorylation → unknown | NES | SIGNOR-250669 |
| CDK5 | phosphorylation → up-regulates | LMTK2 | SIGNOR-195329 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249326 |
| CDK5 | phosphorylation → up-regulates activity | PLD2 | SIGNOR-278395 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276443 |
| CDK5 | phosphorylation → up-regulates | CLOCK | SIGNOR-203227 |
| CDK5 | phosphorylation → down-regulates activity | MEF2D | SIGNOR-279509 |
| CDK5 | phosphorylation → up-regulates activity | TRIM59 | SIGNOR-272929 |
| CDK5 | phosphorylation → up-regulates activity | FOXC2 | SIGNOR-279156 |
| CDK5 | phosphorylation → up-regulates | SYN1 | SIGNOR-78883 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-197945 |
| CDK5 | phosphorylation → up-regulates | AR | SIGNOR-175696 |
| CDK5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279515 |
| CDK5 | phosphorylation down-regulates | NOS3 | SIGNOR-164080 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | BAG3 | SIGNOR-277502 |
| CDK5 | phosphorylation → unknown | PPP1R1A | SIGNOR-249194 |
| CDK5 | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-264838 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-171018 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249324 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92603 |
| CDK5 | phosphorylation down-regulates | PIK3C3 | SIGNOR-165772 |
| CDK5 | phosphorylation → down-regulates activity | TPPP | SIGNOR-262933 |
| CDK5 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-279679 |
| CDK5 | phosphorylation → up-regulates activity | SIRT2 | SIGNOR-279684 |
| CDK5 | phosphorylation → down-regulates activity | PP1 | SIGNOR-264649 |
| CDK5 | phosphorylation down-regulates quantity by destabilization | DLGAP1 | SIGNOR-279153 |
| CDK5 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145971 |
| CDK5 | phosphorylation → up-regulates | NFAT5 | SIGNOR-170886 |
| CDK5 | phosphorylation → unknown | AMPH | SIGNOR-250650 |
| CDK5 | phosphorylation → up-regulates activity | CORO1A | SIGNOR-245187 |
| CDK5 | phosphorylation down-regulates | LMTK2 | SIGNOR-102652 |
| CDK5 | phosphorylation → up-regulates activity | PPP1R1B | SIGNOR-250671 |
| CDK5 | phosphorylation → up-regulates | HTRA2 | SIGNOR-174598 |
| CDK5 | phosphorylation → down-regulates activity | PAK1 | SIGNOR-249328 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156414 |
| CDK5 | phosphorylation down-regulates | STXBP2 | SIGNOR-157528 |
| CDK5 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-92269 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-198111 |
| CDK5 | phosphorylation → up-regulates | SRC | SIGNOR-71950 |
| CDK5 | phosphorylation down-regulates | CDK5R1 | SIGNOR-177963 |
| CDK5 | phosphorylation → unknown | APP | SIGNOR-250651 |
| CDK5 | phosphorylation → up-regulates activity | EZR | SIGNOR-250665 |
| CDK5 | phosphorylation → unknown | AMPH | SIGNOR-250649 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156426 |
| CDK5 | phosphorylation → up-regulates activity | PXN | SIGNOR-278921 |
| CDK5 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-154405 |
| CDK5 | phosphorylation down-regulates | LMTK2 | SIGNOR-102717 |
| CDK5 | phosphorylation → up-regulates | AGAP2 | SIGNOR-178660 |
| CDK5 | phosphorylation → up-regulates activity | APEX1 | SIGNOR-276337 |
| CDK5 | phosphorylation → down-regulates activity | DRD2 | SIGNOR-259401 |
| CDK5 | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-279400 |