| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 11447121 | SIGNOR-250631 |
| AKT1 | HSF1 | Thr527 | PPKAKDPtVS | phosphorylation up-regulates activity | 35080342 | SIGNOR-278371 |
| AKT1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 35080342 | SIGNOR-278372 |
| AKT1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 35080342 | SIGNOR-277579 |
| AKT1 | HSF1 | Thr527 | PPKAKDPtVS | phosphorylation up-regulates activity | 35080342 | SIGNOR-277578 |
| GSK3B | HSF1 | Ser303 | RVKEEPPsPPQSPRV | phosphorylation down-regulates | 8940068 | SIGNOR-44995 |
| MAPKAPK2 | HSF1 | Ser121 | NIKRKVTsVSTLKSE | phosphorylation down-regulates activity | 16278218 | SIGNOR-279541 |
| HIPK3 | HSF1 | – | phosphorylation up-regulates activity | 18793336 | SIGNOR-279054 | |
| MAP2K1 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279209 |
| MAP2K1 | HSF1 | Ser344 | ESEPAPAsVTALTDA | phosphorylation up-regulates activity | 35080342 | SIGNOR-279210 |
| AKT1 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-278374 |
| PRKACA | HSF1 | Ser320 | ASPGRPSsVDTLLSP | phosphorylation up-regulates | 21085490 | SIGNOR-169853 |
| PLK1 | HSF1 | Ser216 | IPLMLNDsGSAHSMP | phosphorylation down-regulates | 18794143 | SIGNOR-180915 |
| MAP2K1 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation up-regulates activity | 35080342 | SIGNOR-279211 |
| MAP2K1 | HSF1 | Ser241 | VHGSGPYsAPSPAYS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279208 |
| AKT2 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279779 |
| DYRK2 | HSF1 | Ser320 | ASPGRPSsVDTLLSP | phosphorylation up-regulates activity | 33268814 | SIGNOR-278355 |
| DYRK2 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 33268814 | SIGNOR-278356 |
| GSK3B | HSF1 | Ser303 | RVKEEPPsPPQSPRV | phosphorylation down-regulates activity | 8940068 | SIGNOR-251216 |
| AKT1 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-277581 |
| AKT1 | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 35080342 | SIGNOR-277580 |
| MAPK8 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation down-regulates activity | 10747973 | SIGNOR-250119 |
| PRKCQ | HSF1 | – | phosphorylation up-regulates | 23352416 | SIGNOR-200576 | |
| MAPK3 | HSF1 | Ser307 | EPPSPPQsPRVEEAS | phosphorylation down-regulates | 8940068 | SIGNOR-44999 |
| CSNK2A1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 12659875 | SIGNOR-250898 |
| CSNK2A2 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates | 12659875 | SIGNOR-99606 |
| AKT1 | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 35080342 | SIGNOR-278373 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 11447121 | SIGNOR-250631 |
| AKT1 | phosphorylation up-regulates → | HSF1 PThr527 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278371 |
| AKT1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278372 |
| AKT1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277579 |
| AKT1 | phosphorylation up-regulates → | HSF1 PThr527 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277578 |
| GSK3B | phosphorylation up-regulates → | HSF1 PSer303 | phosphorylation down-regulates ⊣ | HSF1 | 8940068 | SIGNOR-44995 |
| MAPKAPK2 | phosphorylation up-regulates → | HSF1 PSer121 | phosphorylation down-regulates ⊣ | HSF1 | 16278218 | SIGNOR-279541 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279209 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer344 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279210 |
| AKT1 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278374 |
| PRKACA | phosphorylation up-regulates → | HSF1 PSer320 | phosphorylation up-regulates → | HSF1 | 21085490 | SIGNOR-169853 |
| PLK1 | phosphorylation up-regulates → | HSF1 PSer216 | phosphorylation down-regulates ⊣ | HSF1 | 18794143 | SIGNOR-180915 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279211 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer241 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279208 |
| AKT2 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279779 |
| DYRK2 | phosphorylation up-regulates → | HSF1 PSer320 | phosphorylation up-regulates → | HSF1 | 33268814 | SIGNOR-278355 |
| DYRK2 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 33268814 | SIGNOR-278356 |
| GSK3B | phosphorylation up-regulates → | HSF1 PSer303 | phosphorylation down-regulates ⊣ | HSF1 | 8940068 | SIGNOR-251216 |
| AKT1 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277581 |
| AKT1 | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277580 |
| MAPK8 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation down-regulates ⊣ | HSF1 | 10747973 | SIGNOR-250119 |
| MAPK3 | phosphorylation up-regulates → | HSF1 PSer307 | phosphorylation down-regulates ⊣ | HSF1 | 8940068 | SIGNOR-44999 |
| CSNK2A1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 12659875 | SIGNOR-250898 |
| CSNK2A2 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 12659875 | SIGNOR-99606 |
| AKT1 | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278373 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation → up-regulates activity | HSF1 | SIGNOR-250631 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278371 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278372 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277579 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277578 |
| GSK3B | phosphorylation down-regulates | HSF1 | SIGNOR-44995 |
| MAPKAPK2 | phosphorylation → down-regulates activity | HSF1 | SIGNOR-279541 |
| HIPK3 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279054 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279209 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279210 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278374 |
| PRKACA | phosphorylation → up-regulates | HSF1 | SIGNOR-169853 |
| PLK1 | phosphorylation down-regulates | HSF1 | SIGNOR-180915 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279211 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279208 |
| AKT2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279779 |
| DYRK2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278355 |
| DYRK2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278356 |
| GSK3B | phosphorylation → down-regulates activity | HSF1 | SIGNOR-251216 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277581 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277580 |
| MAPK8 | phosphorylation → down-regulates activity | HSF1 | SIGNOR-250119 |
| PRKCQ | phosphorylation → up-regulates | HSF1 | SIGNOR-200576 |
| MAPK3 | phosphorylation down-regulates | HSF1 | SIGNOR-44999 |
| CSNK2A1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-250898 |
| CSNK2A2 | phosphorylation → up-regulates | HSF1 | SIGNOR-99606 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278373 |
