| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 35080342 | SIGNOR-277580 |
| AKT1 | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 35080342 | SIGNOR-278373 |
| CAMK2A | HSF1 | Ser230 | PKYSRQFsLEHVHGS | phosphorylation up-regulates activity | 11447121 | SIGNOR-250631 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277580 |
| AKT1 | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278373 |
| CAMK2A | phosphorylation up-regulates → | HSF1 PSer230 | phosphorylation up-regulates → | HSF1 | 11447121 | SIGNOR-250631 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277580 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278373 |
| CAMK2A | phosphorylation → up-regulates activity | HSF1 | SIGNOR-250631 |