| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 35080342 | SIGNOR-278372 |
| CSNK2A2 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates | 12659875 | SIGNOR-99606 |
| AKT1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 35080342 | SIGNOR-277579 |
| CSNK2A1 | HSF1 | Thr142 | DSVTKLLtDVQLMKG | phosphorylation up-regulates activity | 12659875 | SIGNOR-250898 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-278372 |
| CSNK2A2 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 12659875 | SIGNOR-99606 |
| AKT1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-277579 |
| CSNK2A1 | phosphorylation up-regulates → | HSF1 PThr142 | phosphorylation up-regulates → | HSF1 | 12659875 | SIGNOR-250898 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278372 |
| CSNK2A2 | phosphorylation → up-regulates | HSF1 | SIGNOR-99606 |
| AKT1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-277579 |
| CSNK2A1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-250898 |