| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | HSF1 | Ser303 | RVKEEPPsPPQSPRV | phosphorylation down-regulates activity | 8940068 | SIGNOR-251216 |
| GSK3B | HSF1 | Ser303 | RVKEEPPsPPQSPRV | phosphorylation down-regulates | 8940068 | SIGNOR-44995 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | HSF1 PSer303 | phosphorylation down-regulates ⊣ | HSF1 | 8940068 | SIGNOR-251216 |
| GSK3B | phosphorylation up-regulates → | HSF1 PSer303 | phosphorylation down-regulates ⊣ | HSF1 | 8940068 | SIGNOR-44995 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | HSF1 | SIGNOR-251216 |
| GSK3B | phosphorylation down-regulates | HSF1 | SIGNOR-44995 |
