| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation down-regulates activity | 10747973 | SIGNOR-250119 |
| MAP2K1 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation up-regulates activity | 35080342 | SIGNOR-279211 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation down-regulates ⊣ | HSF1 | 10747973 | SIGNOR-250119 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279211 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → down-regulates activity | HSF1 | SIGNOR-250119 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279211 |