| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | HSF1 | Ser216 | IPLMLNDsGSAHSMP | phosphorylation down-regulates | 18794143 | SIGNOR-180915 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | HSF1 PSer216 | phosphorylation down-regulates ⊣ | HSF1 | 18794143 | SIGNOR-180915 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates | HSF1 | SIGNOR-180915 |
