| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | HSF1 | Ser320 | ASPGRPSsVDTLLSP | phosphorylation up-regulates activity | 33268814 | SIGNOR-278355 |
| PRKACA | HSF1 | Ser320 | ASPGRPSsVDTLLSP | phosphorylation up-regulates | 21085490 | SIGNOR-169853 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | phosphorylation up-regulates → | HSF1 PSer320 | phosphorylation up-regulates → | HSF1 | 33268814 | SIGNOR-278355 |
| PRKACA | phosphorylation up-regulates → | HSF1 PSer320 | phosphorylation up-regulates → | HSF1 | 21085490 | SIGNOR-169853 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278355 |
| PRKACA | phosphorylation → up-regulates | HSF1 | SIGNOR-169853 |
