| Name | SPTBN1 |
| ID | Q01082 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1 54-158 PROSITE-ProRule
Calponin-homology (CH) 2 173-278 PROSITE-ProRule
PH 2197-2307 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | SPTBN1 | Ser2110 | PEPSTKVsEEAESQQ | phosphorylation down-regulates | 17088250 | SIGNOR-150467 |
| PRKACA | SPTBN1 | Thr2159 | NGATEQRtSSKESSP | phosphorylation down-regulates activity | 17088250 | SIGNOR-250054 |
| CSNK2A1 | SPTBN1 | Thr2159 | NGATEQRtSSKESSP | phosphorylation down-regulates | 17088250 | SIGNOR-150471 |
| TGFBR1 | SPTBN1 | – | phosphorylation up-regulates | 12543979 | SIGNOR-97626 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | SPTBN1 PSer2110 | phosphorylation down-regulates ⊣ | SPTBN1 | 17088250 | SIGNOR-150467 |
| PRKACA | phosphorylation up-regulates → | SPTBN1 PThr2159 | phosphorylation down-regulates ⊣ | SPTBN1 | 17088250 | SIGNOR-250054 |
| CSNK2A1 | phosphorylation up-regulates → | SPTBN1 PThr2159 | phosphorylation down-regulates ⊣ | SPTBN1 | 17088250 | SIGNOR-150471 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation down-regulates | SPTBN1 | SIGNOR-150467 |
| PRKACA | phosphorylation → down-regulates activity | SPTBN1 | SIGNOR-250054 |
| CSNK2A1 | phosphorylation down-regulates | SPTBN1 | SIGNOR-150471 |
| TGFBR1 | phosphorylation → up-regulates | SPTBN1 | SIGNOR-97626 |