| Name | RUNX1 |
| ID | Q01196 |
| Role | substrate |
| Enzymatic Domains |
Runt 50-178 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268219 |
| CyclinB/CDK1 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates | 21059642 | SIGNOR-216912 |
| CDK6 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates | 21059642 | SIGNOR-169326 |
| SRC | RUNX1 | – | phosphorylation up-regulates activity | 26598521 | SIGNOR-279656 | |
| CyclinA2/CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates activity | 17015473 | SIGNOR-217340 |
| ERK1/2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-244711 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-169334 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138961 |
| MAPK1 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268220 |
| CyclinD3/CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-273029 |
| CDK6 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-138953 |
| CDK1 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates | 21059642 | SIGNOR-169318 |
| PIM1 | RUNX1 | – | phosphorylation up-regulates activity | 16684349 | SIGNOR-278976 | |
| CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138936 |
| CDK6 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates | 16046550 | SIGNOR-138957 |
| MAPK1 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates activity | 16046550 | SIGNOR-138981 |
| MAPK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268218 |
| CDK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138916 |
| CyclinB/CDK1 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates | 21059642 | SIGNOR-216916 |
| ERK1/2 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-244703 |
| MAPK1 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates activity | 16046550 | SIGNOR-138973 |
| CDK6 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates | 21059642 | SIGNOR-169330 |
| CyclinD3/CDK6 | RUNX1 | Ser21 | TPPSTALsPGKMSEA | phosphorylation up-regulates activity | 21059642 | SIGNOR-273031 |
| ERK1/2 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates | 16046550 | SIGNOR-244715 |
| CDK2 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates activity | 16046550 | SIGNOR-138928 |
| ERK1/2 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates | 16046550 | SIGNOR-244707 |
| CDK2 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates activity | 16046550 | SIGNOR-138940 |
| CyclinD3/CDK6 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates activity | 21059642 | SIGNOR-273030 |
| CDK1 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates | 16046550 | SIGNOR-138912 |
| MAPK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates activity | 16046550 | SIGNOR-138969 |
| CDK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-138908 |
| MAPK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138985 |
| CDK1 | RUNX1 | Ser397 | SMVGGERsPPRILPP | phosphorylation up-regulates | 21059642 | SIGNOR-169322 |
| CDK2 | RUNX1 | Ser266 | QYLGSIAsPSVHPAT | phosphorylation up-regulates activity | 16046550 | SIGNOR-138932 |
| CDK1 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates | 16046550 | SIGNOR-138920 |
| CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates activity | 17015473 | SIGNOR-149976 |
| MAPK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268221 |
| CDK6 | RUNX1 | Thr273 | SPSVHPAtPISPGRA | phosphorylation up-regulates | 16046550 | SIGNOR-138965 |
| CDK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates quantity by destabilization | 17015473 | SIGNOR-149972 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268219 |
| CyclinB/CDK1 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-216912 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169326 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-217340 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244711 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169334 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138961 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268220 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273029 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138953 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169318 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138936 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138957 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138981 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268218 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138916 |
| CyclinB/CDK1 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-216916 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244703 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138973 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169330 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer21 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273031 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244715 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138928 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244707 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138940 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273030 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138912 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138969 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138908 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138985 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer397 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169322 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer266 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138932 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138920 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-149976 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268221 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PThr273 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138965 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-149972 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268219 |
| CyclinB/CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-216912 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169326 |
| SRC | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-279656 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | RUNX1 | SIGNOR-217340 |
| ERK1/2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-244711 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-169334 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138961 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268220 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273029 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138953 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169318 |
| PIM1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-278976 |
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138936 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138957 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138981 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268218 |
| CDK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138916 |
| CyclinB/CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-216916 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244703 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138973 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169330 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273031 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244715 |
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138928 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244707 |
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138940 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273030 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138912 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138969 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138908 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138985 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-169322 |
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138932 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138920 |
| CDK2 | phosphorylation → down-regulates activity | RUNX1 | SIGNOR-149976 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268221 |
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138965 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-149972 |