| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK6 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-138953 |
| MAPK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268218 |
| ERK1/2 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-244703 |
| CDK2 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates activity | 16046550 | SIGNOR-138928 |
| MAPK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates activity | 16046550 | SIGNOR-138969 |
| CDK1 | RUNX1 | Ser249 | DTRQIQPsPPWSYDQ | phosphorylation up-regulates | 16046550 | SIGNOR-138908 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138953 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268218 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244703 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138928 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138969 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer249 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138908 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK6 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138953 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268218 |
| ERK1/2 | phosphorylation → up-regulates | RUNX1 | SIGNOR-244703 |
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138928 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138969 |
| CDK1 | phosphorylation → up-regulates | RUNX1 | SIGNOR-138908 |
