| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138936 |
| CDK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138916 |
| MAPK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138985 |
| CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates activity | 17015473 | SIGNOR-149976 |
| MAPK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates quantity by destabilization | 16046550 | SIGNOR-268221 |
| CDK1 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates quantity by destabilization | 17015473 | SIGNOR-149972 |
| CyclinA2/CDK2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation down-regulates activity | 17015473 | SIGNOR-217340 |
| ERK1/2 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-244711 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-169334 |
| CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 16046550 | SIGNOR-138961 |
| CyclinD3/CDK6 | RUNX1 | Ser276 | VHPATPIsPGRASGM | phosphorylation up-regulates activity | 21059642 | SIGNOR-273029 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138936 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138916 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138985 |
| CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-149976 |
| MAPK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 16046550 | SIGNOR-268221 |
| CDK1 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-149972 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation down-regulates ⊣ | RUNX1 | 17015473 | SIGNOR-217340 |
| ERK1/2 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-244711 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-169334 |
| CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 16046550 | SIGNOR-138961 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | RUNX1 PSer276 | phosphorylation up-regulates → | RUNX1 | 21059642 | SIGNOR-273029 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138936 |
| CDK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138916 |
| MAPK1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138985 |
| CDK2 | phosphorylation → down-regulates activity | RUNX1 | SIGNOR-149976 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-268221 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | RUNX1 | SIGNOR-149972 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | RUNX1 | SIGNOR-217340 |
| ERK1/2 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-244711 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-169334 |
| CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-138961 |
| CyclinD3/CDK6 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-273029 |
