| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | PFKP | Ser386 | AVRLRGRsFAGNLNT | dephosphorylation down-regulates activity | 29038421 | SIGNOR-277118 |
| CyclinD3/CDK6 | PFKP | Ser679 | MQQGGAPsPFDRNFG | phosphorylation down-regulates activity | 28607489 | SIGNOR-273033 |
| AKT1 | PFKP | – | phosphorylation up-regulates quantity | 29038421 | SIGNOR-279788 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | PFKP PSer386 | dephosphorylation up-regulates → | PFKP | 29038421 | SIGNOR-277118 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PFKP PSer679 | phosphorylation down-regulates ⊣ | PFKP | 28607489 | SIGNOR-273033 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → down-regulates activity | PFKP | SIGNOR-277118 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PFKP | SIGNOR-273033 |
| AKT1 | phosphorylation → up-regulates quantity | PFKP | SIGNOR-279788 |
