Entity Details

Name POU5F1
ID Q01860
Role substrate
Enzymatic Domains
POU-specific 138-212
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1POU5F1Ser111ESNSDGAsPEPCTVTphosphorylation
down-regulates		23024368SIGNOR-192097
CDK7POU5F1Ser12LASDFAFsPPPGGGGphosphorylation
up-regulates quantity by stabilization		31306665SIGNOR-264404
MAPKAPK2POU5F1Ser111ESNSDGAsPEPCTVTphosphorylation
up-regulates activity		32409685SIGNOR-279542
CyclinE/CDK2POU5F1Ser12LASDFAFsPPPGGGGphosphorylation
up-regulates quantity by stabilization		31306665SIGNOR-264438
GbetaPOU5F1–phosphorylation
down-regulates		23024368SIGNOR-270085
ERK1/2POU5F1–phosphorylation
down-regulates		23024368SIGNOR-270185
AKTPOU5F1Thr235QARKRKRtSIENRVRphosphorylation
up-regulates quantity by stabilization		23041284SIGNOR-242092
AURKBPOU5F1–phosphorylation
down-regulates activity		26880562SIGNOR-279592
MAPK3POU5F1Ser111ESNSDGAsPEPCTVTphosphorylation
down-regulates		23024368SIGNOR-192101
CyclinE/CDK2POU5F1Ser12LASDFAFsPPPGGGGphosphorylation
up-regulates quantity by stabilization		31306665SIGNOR-264437
AKT2POU5F1Thr235QARKRKRtSIENRVRphosphorylation
up-regulates quantity by stabilization		23041284SIGNOR-242097
CyclinE/CDK2POU5F1Ser12LASDFAFsPPPGGGGphosphorylation
up-regulates quantity by stabilization		31306665SIGNOR-264436
AKT3POU5F1Thr235QARKRKRtSIENRVRphosphorylation
up-regulates quantity by stabilization		23041284SIGNOR-242107
AKT1POU5F1Thr235QARKRKRtSIENRVRphosphorylation
up-regulates quantity by stabilization		23041284SIGNOR-252545
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
POU5F1
PSer111		phosphorylation
down-regulates
⊣		POU5F123024368SIGNOR-192097
CDK7phosphorylation
up-regulates
→
POU5F1
PSer12		phosphorylation
up-regulates
→		POU5F131306665SIGNOR-264404
MAPKAPK2phosphorylation
up-regulates
→
POU5F1
PSer111		phosphorylation
up-regulates
→		POU5F132409685SIGNOR-279542
CyclinE/CDK2phosphorylation
up-regulates
→
POU5F1
PSer12		phosphorylation
up-regulates
→		POU5F131306665SIGNOR-264438
AKTphosphorylation
up-regulates
→
POU5F1
PThr235		phosphorylation
up-regulates
→		POU5F123041284SIGNOR-242092
MAPK3phosphorylation
up-regulates
→
POU5F1
PSer111		phosphorylation
down-regulates
⊣		POU5F123024368SIGNOR-192101
CyclinE/CDK2phosphorylation
up-regulates
→
POU5F1
PSer12		phosphorylation
up-regulates
→		POU5F131306665SIGNOR-264437
AKT2phosphorylation
up-regulates
→
POU5F1
PThr235		phosphorylation
up-regulates
→		POU5F123041284SIGNOR-242097
CyclinE/CDK2phosphorylation
up-regulates
→
POU5F1
PSer12		phosphorylation
up-regulates
→		POU5F131306665SIGNOR-264436
AKT3phosphorylation
up-regulates
→
POU5F1
PThr235		phosphorylation
up-regulates
→		POU5F123041284SIGNOR-242107
AKT1phosphorylation
up-regulates
→
POU5F1
PThr235		phosphorylation
up-regulates
→		POU5F123041284SIGNOR-252545
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates 		POU5F1SIGNOR-192097
CDK7phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-264404
MAPKAPK2phosphorylation
→
up-regulates activity 		POU5F1SIGNOR-279542
CyclinE/CDK2phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-264438
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates 		POU5F1SIGNOR-270085
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates 		POU5F1SIGNOR-270185
AKTphosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-242092
AURKBphosphorylation
→
down-regulates activity 		POU5F1SIGNOR-279592
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates 		POU5F1SIGNOR-192101
CyclinE/CDK2phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-264437
AKT2phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-242097
CyclinE/CDK2phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-264436
AKT3phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-242107
AKT1phosphorylation
→
up-regulates quantity by stabilization 		POU5F1SIGNOR-252545