Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ERK1/2	POU5F1	–		phosphorylation down-regulates	23024368	SIGNOR-270185
CyclinE/CDK2	POU5F1	Ser12	LASDFAFsPPPGGGG	phosphorylation up-regulates quantity by stabilization	31306665	SIGNOR-264437
CDK7	POU5F1	Ser12	LASDFAFsPPPGGGG	phosphorylation up-regulates quantity by stabilization	31306665	SIGNOR-264404
CyclinE/CDK2	POU5F1	Ser12	LASDFAFsPPPGGGG	phosphorylation up-regulates quantity by stabilization	31306665	SIGNOR-264438
MAPK3	POU5F1	Ser111	ESNSDGAsPEPCTVT	phosphorylation down-regulates	23024368	SIGNOR-192101
AKT3	POU5F1	Thr235	QARKRKRtSIENRVR	phosphorylation up-regulates quantity by stabilization	23041284	SIGNOR-242107
AKT2	POU5F1	Thr235	QARKRKRtSIENRVR	phosphorylation up-regulates quantity by stabilization	23041284	SIGNOR-242097
MAPK1	POU5F1	Ser111	ESNSDGAsPEPCTVT	phosphorylation down-regulates	23024368	SIGNOR-192097
AKT	POU5F1	Thr235	QARKRKRtSIENRVR	phosphorylation up-regulates quantity by stabilization	23041284	SIGNOR-242092
CyclinE/CDK2	POU5F1	Ser12	LASDFAFsPPPGGGG	phosphorylation up-regulates quantity by stabilization	31306665	SIGNOR-264436
AKT1	POU5F1	Thr235	QARKRKRtSIENRVR	phosphorylation up-regulates quantity by stabilization	23041284	SIGNOR-252545
AURKB	POU5F1	–		phosphorylation down-regulates activity	26880562	SIGNOR-279592
MAPKAPK2	POU5F1	Ser111	ESNSDGAsPEPCTVT	phosphorylation up-regulates activity	32409685	SIGNOR-279542
Gbeta	POU5F1	–		phosphorylation down-regulates	23024368	SIGNOR-270085

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinE/CDK2	phosphorylation up-regulates →	POU5F1 PSer12	phosphorylation up-regulates →	POU5F1	31306665	SIGNOR-264437
CDK7	phosphorylation up-regulates →	POU5F1 PSer12	phosphorylation up-regulates →	POU5F1	31306665	SIGNOR-264404
CyclinE/CDK2	phosphorylation up-regulates →	POU5F1 PSer12	phosphorylation up-regulates →	POU5F1	31306665	SIGNOR-264438
MAPK3	phosphorylation up-regulates →	POU5F1 PSer111	phosphorylation down-regulates ⊣	POU5F1	23024368	SIGNOR-192101
AKT3	phosphorylation up-regulates →	POU5F1 PThr235	phosphorylation up-regulates →	POU5F1	23041284	SIGNOR-242107
AKT2	phosphorylation up-regulates →	POU5F1 PThr235	phosphorylation up-regulates →	POU5F1	23041284	SIGNOR-242097
MAPK1	phosphorylation up-regulates →	POU5F1 PSer111	phosphorylation down-regulates ⊣	POU5F1	23024368	SIGNOR-192097
AKT	phosphorylation up-regulates →	POU5F1 PThr235	phosphorylation up-regulates →	POU5F1	23041284	SIGNOR-242092
CyclinE/CDK2	phosphorylation up-regulates →	POU5F1 PSer12	phosphorylation up-regulates →	POU5F1	31306665	SIGNOR-264436
AKT1	phosphorylation up-regulates →	POU5F1 PThr235	phosphorylation up-regulates →	POU5F1	23041284	SIGNOR-252545
MAPKAPK2	phosphorylation up-regulates →	POU5F1 PSer111	phosphorylation up-regulates →	POU5F1	32409685	SIGNOR-279542

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ERK1/2	phosphorylation down-regulates	POU5F1	SIGNOR-270185
CyclinE/CDK2	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-264437
CDK7	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-264404
CyclinE/CDK2	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-264438
MAPK3	phosphorylation down-regulates	POU5F1	SIGNOR-192101
AKT3	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-242107
AKT2	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-242097
MAPK1	phosphorylation down-regulates	POU5F1	SIGNOR-192097
AKT	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-242092
CyclinE/CDK2	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-264436
AKT1	phosphorylation → up-regulates quantity by stabilization	POU5F1	SIGNOR-252545
AURKB	phosphorylation → down-regulates activity	POU5F1	SIGNOR-279592
MAPKAPK2	phosphorylation → up-regulates activity	POU5F1	SIGNOR-279542
Gbeta	phosphorylation down-regulates	POU5F1	SIGNOR-270085