| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | POU5F1 | Ser111 | ESNSDGAsPEPCTVT | phosphorylation down-regulates | 23024368 | SIGNOR-192101 |
| MAPK1 | POU5F1 | Ser111 | ESNSDGAsPEPCTVT | phosphorylation down-regulates | 23024368 | SIGNOR-192097 |
| MAPKAPK2 | POU5F1 | Ser111 | ESNSDGAsPEPCTVT | phosphorylation up-regulates activity | 32409685 | SIGNOR-279542 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | POU5F1 PSer111 | phosphorylation down-regulates ⊣ | POU5F1 | 23024368 | SIGNOR-192101 |
| MAPK1 | phosphorylation up-regulates → | POU5F1 PSer111 | phosphorylation down-regulates ⊣ | POU5F1 | 23024368 | SIGNOR-192097 |
| MAPKAPK2 | phosphorylation up-regulates → | POU5F1 PSer111 | phosphorylation up-regulates → | POU5F1 | 32409685 | SIGNOR-279542 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | POU5F1 | SIGNOR-192101 |
| MAPK1 | phosphorylation down-regulates | POU5F1 | SIGNOR-192097 |
| MAPKAPK2 | phosphorylation → up-regulates activity | POU5F1 | SIGNOR-279542 |
